The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He; Jing Jiang; Di-Xian Luo

doi:10.1016/j.gendis.2020.03.005

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The functions of N6-methyladenosine modification in lncRNAs

更新时间：2022-06-24

- The functions of N6-methyladenosine modification in lncRNAs
- Genes & Diseases Vol. 7, Issue 4, (2020)
- 作者机构：
  
  1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University,Hunan,Changsha,China,410078
  2. Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China,Chenzhou,China,423000
  3. Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China, Chenzhou, 423000, People's Republic of China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.005
  CLC：
- Published：2020，
  
  Published Online：1 December 2020，
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Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs. [J]. Genes & Diseases 7(4).(2020)
DOI：

Rong-Zhang He, Jing Jiang, Di-Xian Luo. The functions of N6-methyladenosine modification in lncRNAs. [J]. Genes & Diseases 7(4).(2020) DOI： 10.1016/j.gendis.2020.03.005.

摘要

Abstract

Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them

N6-methyladenosine (m6A)

which has been shown to play key roles in RNA splicing

stability

nuclear export

and translation

is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out

while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently

several studies reported m6A modification of lncRNAs. In this review

we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

关键词

Keywords

ErasersLncRNAN6-methyladenosineReadersWriters

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