Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells

Lu Yang; Yukai Jing; Danqing Kang; Panpan Jiang; Na Li; Xinrong Zhou; Yan Chen; Lisa S. Westerberg; Chaohong Liu

doi:10.1016/j.gendis.2020.03.004

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Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells

更新时间：2022-06-24

- Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells
- Genes & Diseases Vol. 8, Issue 3, (2021)
- 作者机构：
  
  1. Department of Pathogen Biology, Tongji Medical College, Huazhong University of Science and Technology,Hubei Province,Wuhan,PR China,430030
  2. Department of Immunology, School of Medicine, Yangtze University,Hubei Province,Jingzhou,PR China,434023
  3. Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Hubei Province,Wuhan,PR China,430030
  4. The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical University,GuiZhou Province,Zunyi,PR China,563000
  5. Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm,Sweden,17177
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.004
  CLC：
- Published：2021，
  
  Published Online：1 May 2021，
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Lu Yang, Yukai Jing, Danqing Kang, et al. Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells. [J]. Genes & Diseases 8(3).(2021)
DOI：

Lu Yang, Yukai Jing, Danqing Kang, et al. Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells. [J]. Genes & Diseases 8(3).(2021) DOI： 10.1016/j.gendis.2020.03.004.

摘要

Abstract

Ubiquitin-specific peptidase 18 (USP18) plays an important role in the development of CD11b

dendritic cells (DCs) and Th17 cells

however

its role in the differentiation of other T cell subsets

especially in regulatory T (Treg) cells

is unknown. In our study

we used

Usp18

KO mice to study the loss of USP18 on the impact of Treg cell differentiation and function. We found that USP18 deficiency upregulates the differentiation of Treg cells

which may lead to disrupted homeostasis of peripheral T cells

and downregulates INF-γ

IL-2

IL-17A producing CD4

T cells and INF-γ producing CD8

T cells. Mechanistically

we also found that the upregulation of Tregs is due to elevated expression of CD25 in

Usp18

KO mice. Finally

we found that the suppressive function of

Usp18

KO Tregs is downregulated. Altogether

our study was the first to identify the role of USP18 in Tregs differentiation and its suppressive function

which may provide a new reference for the treatment of Treg function in many autoimmune diseases

and USP18 can be used as a new therapeutic target for precise medical treatment.

关键词

Keywords

CD25Foxp3ICOSRegulator T cellUSP18

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