Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Ding Yao; Yang GangYi; Wu QiNan

doi:10.1016/j.gendis.2020.03.003

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Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

更新时间：2022-06-24

- Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword
- Genes & Diseases Vol. 8, Issue 4, (2021)
- 作者机构：
  
  1. Endocrinology and Nephrology Department, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital,Chongqing,PR China,400030
  2. Endocrinology Department, The Second Affiliated Hospital of the Chongqing Medical University,Chongqing,PR China,400010
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2020.03.003
  CLC：
- Published：2021，
  
  Published Online：1 July 2021，
扫描看全文
Ding Yao, Yang GangYi, Wu QiNan. Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword. [J]. Genes & Diseases 8(4).(2021)
DOI：

Ding Yao, Yang GangYi, Wu QiNan. Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword. [J]. Genes & Diseases 8(4).(2021) DOI： 10.1016/j.gendis.2020.03.003.

摘要

Abstract

Diabetes is an age-related disease

most of which is type 2 diabetes

and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review

we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus

which is the so-called double-edged sword

analysed its possible mechanism

and identified possible research hot spots.

关键词

Keywords

ApoptosisAutophagic dysfunctionInsulin resistanceIslet beta cell dysfunctionType 2 diabetes mellitus

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