Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

Dan Wang; Fengjiao Chen; Tao Zeng; Qingxia Tang; Bing Chen; Ling Chen; Yan Dong; Xiaosong Li

doi:10.1016/j.gendis.2019.12.013

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Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

更新时间：2022-06-24

- Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma
- Genes & Diseases Vol. 8, Issue 2, (2021)
- 作者机构：
  
  1. Department of Clinical Laboratory, People's Hospital of Rongchang District,, Rongchang,Chongqing,PR China,402460
  2. Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University,Chongqing,PR China,400016
  3. Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China,Sichuan Province,Chengdu,PR China,611731
  4. Clinical Molecular Medicine Testing Center, The First Affiliated Hospital of Chongqing Medical University,Chongqing,PR China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.12.013
  CLC：
- Published：2021，
  
  Published Online：1 March 2021，
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Dan Wang, Fengjiao Chen, Tao Zeng, et al. Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma. [J]. Genes & Diseases 8(2).(2021)
DOI：

Dan Wang, Fengjiao Chen, Tao Zeng, et al. Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma. [J]. Genes & Diseases 8(2).(2021) DOI： 10.1016/j.gendis.2019.12.013.

摘要

Abstract

Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip

next-generation sequencing

and/or other methods in recent years

which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth

invasion

and metastasis of various types of human cancers

including hepatocellular carcinoma (HCC)

which is an aggressive

highly malignant

and invasive tumor

and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies

the diagnosis

treatment

and prognosis of HCC will be considerably improved. Therefore

this review is expected to provide recommendations and directions for future lncRNA research for HCC.

关键词

Keywords

ceRNAsHCClncRNAsmiRNAsncRNAssnoRNAs

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