The regulatory roles of aquaporins in the digestive system

Shengtao Liao; Li Gan; Lin Lv; Zhechuan Mei

doi:10.1016/j.gendis.2019.12.011

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The regulatory roles of aquaporins in the digestive system

更新时间：2022-06-24

- The regulatory roles of aquaporins in the digestive system
- Genes & Diseases Vol. 8, Issue 3, (2021)
- 作者机构：
  
  1. Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University,Chongqing,PR China,400010
  2. Teaching and Research Section of Forensic Medicine, College of Basic Medicine, Chongqing Medical University,Chongqing,PR China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.12.011
  CLC：
- Published：2021，
  
  Published Online：1 May 2021，
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Shengtao Liao, Li Gan, Lin Lv, et al. The regulatory roles of aquaporins in the digestive system. [J]. Genes & Diseases 8(3).(2021)
DOI：

Shengtao Liao, Li Gan, Lin Lv, et al. The regulatory roles of aquaporins in the digestive system. [J]. Genes & Diseases 8(3).(2021) DOI： 10.1016/j.gendis.2019.12.011.

摘要

Abstract

quaporins (AQPs) are highly conserved small transmembrane proteins

which are responsible for the water transport across the cell membrane. AQPs are abundantly expressed in numerous types of cells such as epithelial and endothelial cells. The expression of AQP-1

-3

-4

-5

-8 and -9 were found in the digestive system

where these six AQP isoforms serve essential roles including mediating the transmembrane water transport and regulating the secretion of gastrointestinal (GI) fluids

consequently facilitating the digestion and absorption of GI contents. In addition

the expression levels of AQPs are controlled by various factors

and AQPs can stimulate numerous signaling pathways; however

aberrant expression of AQPs in the GI tracts are associated with the initiation and development of numerous diseases. Thus

this review provides an overview of the expression and functions of AQPs in the digestive system.

关键词

Keywords

AquaporinsDigestive systemDistributionFunctionWater transfer

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