M6A modification of circNSUN2 promotes colorectal liver metastasis

Rong-Zhang He; Jing Jiang; Di-Xian Luo

doi:10.1016/j.gendis.2019.12.002

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M6A modification of circNSUN2 promotes colorectal liver metastasis

更新时间：2022-06-24

- M6A modification of circNSUN2 promotes colorectal liver metastasis
- Genes & Diseases Vol. 8, Issue 1, (2021)
- 作者机构：
  
  1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University,Hunan,Changsha,PR China,410078
  2. Translational Medicine Institute, National & Local Joint Engineering Laboratory for High-through Molecular Diagnosis Technology, Collaborative Research Center for Post-doctoral Mobile Stations of Central South University, Affiliated the First People's Hospital of Chenzhou, University of South China,Hunan,Chenzhou,PR China,423000
  3. Center for Clinical Pathology, The First People's Hospital of Chenzhou, University of South China,Hunan,Chenzhou,PR China,423000
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.12.002
  CLC：
- Published：2021，
  
  Published Online：1 January 2021，
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Rong-Zhang He, Jing Jiang, Di-Xian Luo. M6A modification of circNSUN2 promotes colorectal liver metastasis. [J]. Genes & Diseases 8(1).(2021)
DOI：

Rong-Zhang He, Jing Jiang, Di-Xian Luo. M6A modification of circNSUN2 promotes colorectal liver metastasis. [J]. Genes & Diseases 8(1).(2021) DOI： 10.1016/j.gendis.2019.12.002.

摘要

Abstract

Circular RNAs (circRNAs) are playing emerging role in the pathogenesis of cancers

but the mechanisms still unknown. In the recent issue of the

Nature Communications

Chen and colleagues have demonstrated that YTHDC1 facilitates N6-methyladenosine modified circNSUN2 cytoplasmic export and the circNSUN2/IGF2BP2/HMGA2 complex stabilizes HMGA2 to promote colorectal liver metastasis. These discoveries not only expand our understanding of circRNAs biology in tumor

but also demonstrate that m6A modification plays a key role for circRNAs in RNA metabolism. Therefore

these findings indicate that circRNAs may be a new approach for therapeutic target of cancers.

关键词

Keywords

CircRNAsColorectal carcinomaIGF2BP2MetastasisN6-methyladenosine

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