Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives

Qian Yuan; Xiao-dong Li; Si-miao Zhang; Hong-wei Wang; Yun-liang Wang

doi:10.1016/j.gendis.2019.12.001

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Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives

更新时间：2022-06-24

- Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives
- Genes & Diseases Vol. 8, Issue 2, (2021)
- 作者机构：
  
  1. Department of Neurology, The Second Affiliated Hospital of Zhengzhou University,Henan Province,Zhengzhou,PR China,450014
  2. Department of Neurology, Zhengzhou Central Hospital,Henan Province,Zhengzhou,PR China,450014
  3. Department of Medicine, The University of Chicago,IL,USA,60637
  4. Department of Neurology, The 960th Hospital of Chinese PLA,Shandong Province,Zibo,PR China,255300
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.12.001
  CLC：
- Published：2021，
  
  Published Online：1 March 2021，
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Qian Yuan, Xiao-dong Li, Si-miao Zhang, et al. Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives. [J]. Genes & Diseases 8(2).(2021)
DOI：

Qian Yuan, Xiao-dong Li, Si-miao Zhang, et al. Extracellular vesicles in neurodegenerative diseases: Insights and new perspectives. [J]. Genes & Diseases 8(2).(2021) DOI： 10.1016/j.gendis.2019.12.001.

摘要

Abstract

Extracellular vesicles (EVs) are vesicle-like substances released by eukaryotic cells. Based on their origin and size

EVs are mainly divided into exosomes

microvesicles and apoptotic bodies

and they are secreted by eukaryotic cells under physiological and pathological conditions. EVs are enriched with nucleic acids

proteins and other factors. EVs can regulate the function of adjacent and distant cells

and they are even involved in the pathogenesis of diseases. They contain proteins associated with the pathogenesis of neurodegenerative diseases (NDs)

such as the α-synuclein (α-syn) and tau proteins

which suggest potential roles for EVs as biomarkers and carriers of drugs and other therapeutic molecules that can cross the blood–brain barrier to treat NDs. In this review

we summarized the function of EVs in the pathogenesis of different NDs and related advances in EVs as diagnostic biomarkers and treatments for diseases.

关键词

Keywords

BiomarkerExosomesExtracellular vesiclesNeurodegenerative diseases

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