Epigenetic regulation of prostate cancer

Ruixin Wang; Xiaoqi Liu

doi:10.1016/j.gendis.2019.10.018

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Epigenetic regulation of prostate cancer

更新时间：2022-06-24

- Epigenetic regulation of prostate cancer
- Genes & Diseases Vol. 7, Issue 4, (2020)
- 作者机构：
  
  1. Department of Biochemistry, Purdue University, West Lafayette,IN,USA,47907
  2. Department of Toxicology and Cancer Biology, University of Kentucky,KY,Lexington,USA,40536
  3. Markey Cancer Center, University of Kentucky,KY,Lexington,USA,40536
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.10.018
  CLC：
- Published：2020，
  
  Published Online：1 December 2020，
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Ruixin Wang, Xiaoqi Liu. Epigenetic regulation of prostate cancer. [J]. Genes & Diseases 7(4).(2020)
DOI：

Ruixin Wang, Xiaoqi Liu. Epigenetic regulation of prostate cancer. [J]. Genes & Diseases 7(4).(2020) DOI： 10.1016/j.gendis.2019.10.018.

摘要

Abstract

Prostate cancer is (PCa) the second leading cause of cancer death in males in the United State

with 174

650 new cases and 31

620 deaths estimated in 2019. It has been documented that epigenetic deregulation such as histone modification and DNA methylation contributes to PCa initiation and progression. EZH2 (enhancer of zeste homolog 2)

the catalytic subunit of the Polycomb Repressive Complex (PRC2) responsible for H3K27me3 and gene repression

has been identified as a promising target in PCa. In addition

overexpression of other epigenetic regulators such as DNA methyltransferases (DNMT) is also observed in PCa. These epigenetic regulators undergo extensive post-translational modifications

in particular

phosphorylation. AKT

CDKs

PLK1

PKA

ATR and DNA-PK are the established kinases responsible for phosphorylation of various epigenetic regulators.

关键词

Keywords

DNMTEpigeneticsEZH2HDACPhosphorylationProstate cancer

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