Alternative polyadenylation of mRNA and its role in cancer

Fuwen Yuan; William Hankey; Eric J. Wagner; Wei Li; Qianben Wang

doi:10.1016/j.gendis.2019.10.011

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Alternative polyadenylation of mRNA and its role in cancer

更新时间：2022-06-24

- Alternative polyadenylation of mRNA and its role in cancer
- Genes & Diseases Vol. 8, Issue 1, (2021)
- 作者机构：
  
  1. Department of Pathology, Duke University School of Medicine,NC,Durham,USA,27710
  2. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston,TX,Galveston,USA,77555
  3. Department of Biological Chemistry, University of California, Irvine,CA,USA,92697
  4. Duke Cancer Institute Center for Prostate and Urologic Cancers, Duke University School of Medicine,NC,Durham,USA,27710
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.10.011
  CLC：
- Published：2021，
  
  Published Online：1 January 2021，
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Fuwen Yuan, William Hankey, Eric J. Wagner, et al. Alternative polyadenylation of mRNA and its role in cancer. [J]. Genes & Diseases 8(1).(2021)
DOI：

Fuwen Yuan, William Hankey, Eric J. Wagner, et al. Alternative polyadenylation of mRNA and its role in cancer. [J]. Genes & Diseases 8(1).(2021) DOI： 10.1016/j.gendis.2019.10.011.

摘要

Abstract

lternative polyadenylation (APA) is a molecular process that generates diversity at the 3′ end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript

and results in the differential inclusion of sequence information at the 3′ end. While APA can occur between two PASs allowing for generation of transcripts with distinct coding potential from a single gene

most APA occurs within the untranslated region (3′UTR) and changes the length and content of these non-coding sequences. APA within the 3′UTR can have tremendous impact on its regulatory potential of the mRNA through a variety of mechanisms

and indeed this layer of gene expression regulation has profound impact on processes vital to cell growth and development. Recent studies have particularly highlighted the importance of APA dysregulation in cancer onset and progression. Here

we review the current knowledge of APA and its impacts on mRNA stability

translation

localization and protein localization. We also discuss the implications of APA dysregulation in cancer research and therapy.

关键词

Keywords

3′ untranslated regionAlternative polyadenylationCancerGene regulationPolyadenylation signals

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