Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

Jun Wan; Hongji Dai; Xiaoli Zhang; Sheng Liu; Yuan Lin; Ally-Khan Somani; Jingwu Xie; Jiali Han

doi:10.1016/j.gendis.2019.10.004

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Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

更新时间：2022-06-24

- Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas
- Genes & Diseases Vol. 8, Issue 2, (2021)
- 作者机构：
  
  1. Department of Medical and Molecular Genetics, Indiana University School of Medicine,IN,Indianapolis,USA,46202
  2. Center for Computational Biology and Bioinformatics, Indiana University School of Medicine,IN,Indianapolis,USA,46202
  3. School of Informatics and Computing, Indiana University – Purdue University at Indianapolis,IN,Indianapolis,USA,46202
  4. Department of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital,Tianjin,PR China,300000
  5. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine,IN,Indianapolis,USA,46202
  6. Melvin and Bren Simon Cancer Center, Indiana University School of Medicine,IN,Indianapolis,USA,46202
  7. Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University,IN,Indianapolis,USA,46202
  8. Dermatologic Surgery & Cutaneous Oncology Division, Department of Dermatology, Indiana University School of Medicine,IN,Indianapolis,USA,46202
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.10.004
  CLC：
- Published：2021，
  
  Published Online：1 March 2021，
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Jun Wan, Hongji Dai, Xiaoli Zhang, et al. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas. [J]. Genes & Diseases 8(2).(2021)
DOI：

Jun Wan, Hongji Dai, Xiaoli Zhang, et al. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas. [J]. Genes & Diseases 8(2).(2021) DOI： 10.1016/j.gendis.2019.10.004.

摘要

Abstract

The majority of non-melanoma skin cancer (NMSC) is cutaneous basal cell carcinoma (BCC) or squamous cell carcinoma (SCC)

which are also called keratinocyte carcinomas

as both of them originate from keratinocytes. The incidence of keratinocyte carcinomas is over 5 million per year in the US

three-fold higher than the total incidence of all other types of cancer combined. While there are several reports on gene expression profiling of BCC and SCC

there are significant variations in the reported gene expression changes in different studies. One reason is that tumor-adjacent normal skin specimens were not included in many studies as matched controls. Furthermore

while numerous studies of skin stem cells in mouse models have been reported

their relevance to human skin cancer remains unknown. In this report

we analyzed gene expression profiles of paired specimens of keratinocyte carcinomas with their matched normal skin tissues as the control. Among several novel findings

we discovered a significant number of zinc finger encoding genes up-regulated in human BCC. In BCC

a novel link was found between hedgehog signaling

Wnt signaling

and the cilium. While the SCC cancer-stem-cell gene signature is shared between human and mouse SCCs

the hair follicle stem-cell signature of mice was not highly represented in human SCC. Differential gene expression (DEG) in human BCC shares gene signature with both bulge and epidermal stem cells. We have also determined that human BCCs and SCCs have distinct gene expression patterns

and some of them are not fully reflected in current mouse models.

关键词

Keywords

Basal cell carcinomaGli1Hedgehog signalingPTCH1Squamous cell carcinoma

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