ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells

Luca Tirinato; Francesca Pagliari; Simone Di Franco; Elisa Sogne; Maria Grazia Marafioti; Jeanette Jansen; Andrea Falqui; Matilde Todaro; Patrizio Candeloro; Carlo Liberale; Joao Seco; Giorgio Stassi; Enzo Di Fabrizio

doi:10.1016/j.gendis.2019.09.010

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ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells

更新时间：2022-06-24

- ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells
- Genes & Diseases Vol. 7, Issue 4, (2020)
- 作者机构：
  
  1. Biomedical Physics in Radiation Oncology, DKFZ (German Cancer Research Center), Heidelberg,Germany,69120
  2. Physical Science and Engineering (PSE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
  3. Department of Experimental and Clinical Medicine, University “Magna Graecia” of Catanzaro, Loc88100. Germaneto,Catanzaro,Italy
  4. Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
  5. Cellular and Molecular Pathophysiology Laboratory, Department of Surgical, Oncological and Stomatological Sciences, University of Palermo,Palermo,Italy
  6. Ruprecht Karls University Heidelberg, Department of Physics, Heidelberg,Germany,69120
  7. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo,Palermo,Italy
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.09.010
  CLC：
- Published：2020，
  
  Published Online：1 December 2020，
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Luca Tirinato, Francesca Pagliari, Simone Di Franco, et al. ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells. [J]. Genes & Diseases 7(4).(2020)
DOI：

Luca Tirinato, Francesca Pagliari, Simone Di Franco, et al. ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells. [J]. Genes & Diseases 7(4).(2020) DOI： 10.1016/j.gendis.2019.09.010.

摘要

Abstract

Lipid Droplets (LDs) are emerging as crucial players in colon cancer development and maintenance. Their expression has been associated with high tumorigenicity in Cancer Stem Cells (CSCs)

so that they have been proposed as a new functional marker in Colorectal Cancer Stem Cells (CR-CSCs). They are also indirectly involved in the modulation of the tumor microenvironment through the production of pro-inflammatory molecules. There is growing evidence that a possible connection between metabolic alterations and malignant transformation exists

although the effects of nutrients

primarily glucose

on the CSC behavior are still mostly unexplored. Glucose is an essential fuel for cancer cells

and the connections with LDs in the healthy and CSC populations merit to be more deeply investigated. Here

we showed that a high glucose concentration activated the PI3K/AKT pathway and increased the expression of CD133 and CD44v6 CSC markers. Additionally

glucose was responsible for the increased amount of Reactive Oxygen Species (ROS) and LDs in both healthy and CR-CSC samples. We also investigated the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most affected. Lastly

Atorvastatin

a lipid-lowering drug

induced the highest mortality on CR-CSCs without affecting the healthy counterpart.

关键词

Keywords

Cholesterol metabolismColorectal cancer stem cellsFatty acid metabolismHigh glucoseLipid dropletsOncogenesOxidative stressPI3K-AKT

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