Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism

Wei Liu; Zhongliang Deng; Zongyue Zeng; Jiaming Fan; Yixiao Feng; Xi Wang; Daigui Cao; Bo Zhang; Lijuan Yang; Bin Liu; Mikhail Pakvasa; William Wagstaff; Xiaoxing Wu; Huaxiu Luo; Jing Zhang; Meng Zhang; Fang He; Yukun Mao; Yulong Zou

doi:10.1016/j.gendis.2019.08.003

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Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism

更新时间：2022-06-24

- Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism
- Genes & Diseases Vol. 7, Issue 2, (2020)
- 作者机构：
  
  1. Departments of Orthopedic Surgery, Breast Surgery, Gastrointestinal Surgery, Obstetrics and Gynecology, and Nephrology, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  2. Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center,IL,Chicago,USA,60637
  3. Department of Orthopaedic Surgery, The Second Affiliated Hospital of Chongqing Medical University,Chongqing,China,400010
  4. Ministry of Education Key Laboratory of Diagnostic Medicine, The School of Laboratory Medicine, Chongqing Medical University,Chongqing,China,400016
  5. Departments of Orthopaedic Surgery and Laboratory Diagnostic Medicine, Chongqing General Hospital,Chongqing,China,400021
  6. Key Laboratory of Orthopaedic Surgery of Gansu Province, The Departments of Orthopaedic Surgery and Obstetrics and Gynecology, The First and Second Hospitals of Lanzhou University,Lanzhou,China,730030
  7. School of Life Sciences, Southwest University,Chongqing,China,400715
  8. Department of Burn and Plastic Surgery, West China Hospital of Sichuan University,Chengdu,China,610041
  9. Department of Orthopaedic Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,China,510405
  10. Department of Orthopaedic Surgery, The Affiliated Zhongnan Hospital of Wuhan University,Wuhan,China,430072
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.08.003
  CLC：
- Published：2020，
  
  Published Online：1 June 2020，
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Wei Liu, Zhongliang Deng, Zongyue Zeng, et al. Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism. [J]. Genes & Diseases 7(2).(2020)
DOI：

Wei Liu, Zhongliang Deng, Zongyue Zeng, et al. Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation, angiogenesis, tumor growth and metabolism. [J]. Genes & Diseases 7(2).(2020) DOI： 10.1016/j.gendis.2019.08.003.

摘要

Abstract

Bone morphogenetic protein 9 (BMP9) (or GDF2) was originally identified from fetal mouse liver cDNA libraries. Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis. However

the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed. Here

we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice. By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain

adult lungs and adult placenta. We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages. We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice

but decreased in older mice. Interestingly

Bmp9 was only expressed at low to modest levels in developing bones. BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs. Furthermore

the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues. However

the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups

as well as in kidney

liver and lungs in a biphasic fashion. Thus

our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood.

关键词

Keywords

BMP9/GDF2Bone morphogenetic proteins (BMPs)Hepatic metabolismmesenchymal stem cellsNeurogenesisOsteogenic differentiationPulmonary arterial hypertensionTumorigenesis

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