CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage

Chunli Li; Xuemei Chen; Xueqing Liu; Xiaoli Liu; Junlin He; Yubin Ding; Chao Tong; Chuan Peng; Yingxiong Wang; Rufei Gao

doi:10.1016/j.gendis.2019.06.003

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CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage

更新时间：2022-06-24

- CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage
- Genes & Diseases Vol. 7, Issue 3, (2020)
- 作者机构：
  
  1. Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University,Chongqing,China,400016
  2. Department of Clinical Laboratory, Chongqing Health Center for Women and Children,Chongqing,China,401174
  3. Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University,Chongqing,China,400016
  4. Department of Family Planning, Chongqing Health Center for Women and Children,Chongqing,PR China,401174
  5. Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
  6. Laboratory of Maternal and Fetal Medicine, The First Affiliated Hospital of Chongqing Medical University,Chongqing,China,400016
- 作者简介：
- 基金信息：
- DOI：10.1016/j.gendis.2019.06.003
  CLC：
- Published：2020，
  
  Published Online：1 September 2020，
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Chunli Li, Xuemei Chen, Xueqing Liu, et al. CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage. [J]. Genes & Diseases 7(3).(2020)
DOI：

Chunli Li, Xuemei Chen, Xueqing Liu, et al. CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage. [J]. Genes & Diseases 7(3).(2020) DOI： 10.1016/j.gendis.2019.06.003.

摘要

Abstract

Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs that play important roles in gene expression regulation. This study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage (RM). We constructed circRNA expression profiles in decidual tissue using microarray data. A total of 123 differentially expressed circRNAs

including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group (P < 0.05). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis also revealed the enrichment of specific circRNAs. The verified circRNA-targeted miRNA-mRNA network was constructed

most of the circRNAs harbored miRNA binding sites. The network involved 3 circRNAs

27 microRNAs and 82 mRNAs. Hsa_circRNA_103092- miR-224-PRLR network was selected to verify by qRT-PCR. These results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early RM. It gives new insights into the mechanism of recurrent miscarriage.

关键词

Keywords

Circular RNAsDecidual tissueEarly recurrent miscarriageExpression profilesMicroarray

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