Effects of intravesical ATP and PPADS on function of normal and detrusor instable bladders of rats

GUO Jian-jun; FANG Qiang; SONG Bo; LI Long-kun; LI Wei-bing

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Effects of intravesical ATP and PPADS on function of normal and detrusor instable bladders of rats

更新时间：2025-01-15

- Effects of intravesical ATP and PPADS on function of normal and detrusor instable bladders of rats
- Journal of Army Medical University Vol. 29, Issue 3, Pages: 225-227(2007)
- 作者机构：
  
  第三军医大学西南医院全军泌尿外科研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R334.3;R694.5;R-332
- Published：2007，
  
  Published Online：15 February 2007，
- 稿件说明：
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GUO JIAN-JUN, FANG QIANG, SONG BO, et al. Effects of intravesical ATP and PPADS on function of normal and detrusor instable bladders of rats. [J]. Journal of army medical university, 2007, 29(3): 225-227.
DOI：

GUO JIAN-JUN, FANG QIANG, SONG BO, et al. Effects of intravesical ATP and PPADS on function of normal and detrusor instable bladders of rats. [J]. Journal of army medical university, 2007, 29(3): 225-227. DOI：

摘要

目的初步探讨膀胱内给予三磷酸腺苷（ATP）、磷酸吡哆醛（PPADS）对正常及逼尿肌不稳定（detrusor in stability

DI)大鼠膀胱功能的影响。方法建立雌性SD大鼠DI模型，以正常雌性大鼠作对照，分别膀胱内给予嘌呤能受体激动剂ATP和阻滞剂PPADS，行充盈性膀胱测压，观察正常和DI大鼠膀胱贮尿期和排尿期功能的改变。结果成功建立了稳定的DI大鼠模型，成功率72％。ATP使两组大鼠膀胱功能容量减小，排尿间隔时间缩短，正常无DI大鼠70％发生逼尿肌不稳定收缩。PPADS使两组大鼠膀胱功能容量增加，排尿间隔时间延长，DI组大鼠不稳定收缩频率显著降低（

0.05）。结论嘌呤能受体在膀胱排尿反射和逼尿肌不稳定发生中起重要作用。

Abstract

Objective To explore the effects of intravesical adenosine triphosphate (ATP) and pyridoxalphosphate-6-azophenyl-2’4’-disulfonic (PPADS) on the function of normal and detrusor instable bladders of rats. Methods The model of bladder outlet obstruction (BOO) was inflicted in 30 female Sprague-Dawleys (SD) rats. Another normal 15 female SD rats served as control. After 6 weeks

a catheter was implanted into the rat bladder. Three days later

a cystometry was performed in conscious state. The rats were divided into stable and unstable groups. After a bolus infusion of ATP or PPADS into bladder

a same cystometry was performed in the conscious unstable BOO rats and the stabl

e normal rats again. Cytometric parameters were evaluated before and after drug administration. Results There was 72% detrusor instability (DI) in BOO rats. The ATP decreased the functional bladder capacity

shortened the interval-voiding time in both DI group and normal rats without DI. 70% normal rats without DI were induced detrusor instable contractions. PPADS increased the functional bladder capacity

prolonged the interval-voiding time in both groups. Specially

the frequency of instable contractions in DI rats was obviously decreased (

0.05). Conclusion Purinoceptors play important roles in bladder micturition reflex and detrusor instable contractions.

关键词

ATP逼尿肌不稳定

Keywords

adenosine triphosphatedetrusor instability

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