Role of a transcription factor CaRF in skin wound healing in rats

XIE Jiang; LI Ting-yu; ZHU Hu; ZENG Li-ling; ZHONG Yao-hua; CHE Xiao-zhang

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Role of a transcription factor CaRF in skin wound healing in rats

更新时间：2025-01-15

- Role of a transcription factor CaRF in skin wound healing in rats
- Journal of Army Medical University Vol. 29, Issue 3, Pages: 207-209(2007)
- 作者机构：
  
  1. 重庆医科大学儿童医院营养中心
  2. 香港中文大学生理系上皮细胞研究中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R363.22;R-332;R641
- Published：2007，
  
  Published Online：15 February 2007，
- 稿件说明：
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XIE JIANG, LI TING-YU, ZHU HU, et al. Role of a transcription factor CaRF in skin wound healing in rats. [J]. Journal of army medical university, 2007, 29(3): 207-209.
DOI：

XIE JIANG, LI TING-YU, ZHU HU, et al. Role of a transcription factor CaRF in skin wound healing in rats. [J]. Journal of army medical university, 2007, 29(3): 207-209. DOI：

摘要

目的探讨转录因子(calcium-responsive factor

CaRF)在大鼠皮肤创面愈合中的作用。方法建立大鼠背部皮肤全层切割伤模型，随机将大鼠分为3组：盐水对照组，CaRF过表达处理组，CaRF RNAi处理组，以脂质体转染的方式将CaRF和CaRF RNAi导入创面组织，观察3组大鼠背部皮肤伤口愈合状况。结果 CaRF过表达组大鼠皮肤愈合快

愈合质量好，CaRF RNAi 组大鼠皮肤愈合最慢，愈合质量差。结论 CaRF促进大鼠皮肤创面愈合，为临床创面愈合提供了新的思路。

Abstract

Objective To investigate the roles of calcium-responsive factor (CaRF)

a transcription factor

in wound healing. Methods An excision of 1 cm×1 cm full thickness wound were inflicted on the backs of SD rats

and then the rats were randomly divided into 3 groups

saline control

CaRF RNAi treatment

CaRF over-expression treatment

with the animals of later 2 groups receiving CaRF or CaRF RNAi by lipofectin transfection. The progress of wound healing was observed by wound healing index

morphological changes

contents of hydroxyamino acid and total protein in granulation tissues

and the expression of CaRF at the 3rd

7th

14th day post-injury respectively. Results CaRF RNAi treated group showed slower wound healing while the healing in the CaRF over-expressed group was faster and better with an extra reduction of 28.6 % in wound as compared to control groups. Conclusion The transcription factor CaRF may be involved in wound healing

which may provide a foundation for the development of new treatment strategy for wound healing after skin injury.

关键词

创伤愈合CaRF大鼠

Keywords

wound healingcalcium-responsive factorrat

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Related Institution

Department of Nutrition, Second Affiliated Hospital, Army Medical University（Third Military Medical University）

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns, Southwest Hospital, Third Military Medical University

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