Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas

SHI Quan-hong; LIAO Zheng-bu; ZHI Xing-gang; TANG Xiong-wei

您当前的位置：

首页 >

文章列表页 >

Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas

更新时间：2025-01-15

- Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas
- Journal of Army Medical University Vol. 29, Issue 3, Pages: 253-255(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经外科
  2. 重庆合川市人民医院外三科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R394.3;R739.41;R730.23
- Published：2007，
  
  Published Online：15 February 2007，
- 稿件说明：
移动端阅览
SHI QUAN-HONG, LIAO ZHENG-BU, ZHI XING-GANG, et al. Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas. [J]. Journal of army medical university, 2007, 29(3): 253-255.
DOI：

SHI QUAN-HONG, LIAO ZHENG-BU, ZHI XING-GANG, et al. Expression of survivin and its relationship with bcl-2 and bax expressions in meningiomas. [J]. Journal of army medical university, 2007, 29(3): 253-255. DOI：

摘要

目的探讨凋亡抑制基因survivin在脑膜瘤的表达，及其与bcl-2、bax的相关性。方法应用免疫组织化学S-P法，检测60例脑膜瘤瘤组织中survivin、bcl-2、bax蛋白的表达，并结合临床病理参数进行综合分析。结果脑膜瘤Ⅰ级中survivin蛋白表达率为32.0%，Ⅱ级为60.0%，Ⅲ级为86.7%，各级之间survivin蛋白表达率的差异有统计学意义（

＜0.05），并且survivin蛋白的表达与肿瘤的侵袭行为、瘤周水肿显著相关(

＜0.05)；survivin表达与bcl-2表达呈正相关（

＜0.05），与bax表达呈负相关（

＜0.05）。结论 survivin在脑膜瘤的表达与其恶性程度有关，随恶性程度升高而增高，因此survivin可能通过抑制脑膜瘤细胞凋亡，对脑膜瘤的发生、发展起一定作用；survivin与bcl-2、bax在脑膜瘤的发生、发展中分别起协同和拮抗作用。

Abstract

Objective To study the expression of apoptosis inhibited gene survivin and its relationship with the expressions of bcl-2 and bax in meningiomas. Methods Expressions of survivin

bcl-2 and bax proteins were detected by immunohistochemical method (S-P) in 60 samples of meningiomas respectively. The correlation between them was analyzed in combination with clinical pathological data. Results The expression rate of survivin protein was 32.0% in gradeⅠ

60.0%

in grade Ⅱ

and 86.7% in gradeⅢ

with significant differences among the 3 groups (

＜0.05). The

positive ratio was closely correlated with aggressive behavior (

＜0.05) and peritumoral edema (

＜0.05) respectively. Expressions of bcl-2 and bax proteins was positively and negatively correlated with the expression of survivin protein respectively. Conclusion The expression of survivin in meningiomas is closely correlated with its malignancy. Survivin may play an important role in the pathogenesis of malignant meningiomas. Bcl-2 may play a synergic role while bax an antagonistic role to survivin gene in the formation and progression of meningiomas.

关键词

脑膜瘤Survivin细胞凋亡Bcl-2Bax

Keywords

meningiomassurvivinapoptosisBcl-2Bax

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of esmolol on cardiomyocyte apoptosis in septic rats

Lycium barbarum polysaccharide inhibits apoptosis of intestinal epithelial cells through mitochondrial pathway in mice with radiation-induced intestinal injury

Crocin induces apoptosis of bladder transitional cell carcinoma cell line T24

Morphological changes of mitochondria in apoptosis of human ovarian cancer cells induced by arsenic trioxide in vitro

Effect of imitated CO₂ pneumoperitoneum on expressions of Survivin and Bcl-2 in human cervical carcinoma cell line

Related Author

SI Fei

ZHEN Lingling

WANG Yingzhen

ZHANG Bei

ZHANG Hongbin

TENG Jingqian

MA Li

ZHANG Lei

Related Institution

兰州大学：第二临床医学院，第二医院急危重症科3病区

Department of Nuclear Medicine, the First Affiliated Hospital of Chongqing Medical University

Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University

Department of Pathology, Chongqing Medical University

Department of Obstetrics and Gynecology, The First Affiliated Hospital, Chongqing Medical University

⁰