Combination of hyperthermia and LPS may advance and augment systemic inflammatory response syndrome in rats

LI Zhi-liang; ZHAO Ting-bao; LIU Hong-hua

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Combination of hyperthermia and LPS may advance and augment systemic inflammatory response syndrome in rats

更新时间：2025-01-15

- Combination of hyperthermia and LPS may advance and augment systemic inflammatory response syndrome in rats
- Journal of Army Medical University Vol. 29, Issue 6, Pages: 479-481(2007)
- 作者机构：
  
  1. 南方医科大学:珠江医院心血管内科, 护理学院
  2. 济南军区总医院脊髓修复科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R363.123;R593.02;R392.11
- Published：2007，
  
  Published Online：30 March 2007，
- 稿件说明：
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LI ZHI-LIANG, ZHAO TING-BAO, LIU HONG-HUA. Combination of hyperthermia and LPS may advance and augment systemic inflammatory response syndrome in rats. [J]. Journal of army medical university, 2007, 29(6): 479-481.
DOI：

LI ZHI-LIANG, ZHAO TING-BAO, LIU HONG-HUA. Combination of hyperthermia and LPS may advance and augment systemic inflammatory response syndrome in rats. [J]. Journal of army medical university, 2007, 29(6): 479-481. DOI：

摘要

目的探讨高温与脂多糖(LPS)复合应激大鼠血浆TNF-α、IL-6以及氧自由基MDA含量、SOD活力等指标的变化规律。方法将雄性SPF级Wistar大鼠分为：常温生理盐水组(C组)、高温生理盐水组(H组)、常温LPS组(L组)、高温LPS组(HL组)。HL、L组动物经尾静脉注射LPS 10 mg/kg (浓度为1 mg/ml)，H、C组动物经尾静脉注射0.9% NaCl 10 ml/kg。检测动物应激0、40、80、120 min时血浆TNF-α、IL-6、MDA含量及SOD活力的变化。结果 ①HL组于应激40 min时血浆TNF-α、IL-6水平即显著升高，TNF-α峰值(80 min)显著高于其他各组TNF-α水平，IL-6表达水平极度升高，显著高于同时相各组。②应激40 min时HL组动物血浆MDA水平显著升高，SOD活力水平显著下降，与同时相各组比较差异有统计学意义(

0.05)。结论高温与LPS复合应激可能促发、扩大全身炎症反应综合征。

Abstract

Objective To investigate the effects of co-exposure to LPS and heat on plasma tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in rats. Methods Male pathogen-free Wistar rats were randomly assigned to the following groups: saline-injected normothermic control (Group C)

saline-injected heat exposure (Group H)

LPS-injected normothermic control (Group L)

LPS-injected heat exposure (Group HL). Mean arterial pressure (MAP) was continually monitored. Plasma levels of TNF-α

IL-6

MDA and SOD were determined at 0

120 min. Results The rats in Group HL displayed much lower MAP

higher MDA and lower SOD than the other 3 groups. The rats in Group HL displayed an early rise in plasma TNF-α

IL-6 at 40 min

the peak values of both at 80 min significantly higher than the other three groups at the same time piont. Conclusion Co-exposure to LPS and heat primes the rats to advance and augment systemic inflammatory response syndrome.

关键词

过热脂多糖全身炎症反应综合征肿瘤坏死因子-α白细胞介素-6丙二醛超氧化物歧化酶

Keywords

hyperthermiaLPSsystemic inflammatory response syndromeTNF-αIL-6MDASOD

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