Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients

WANG Hong-jun; LI Hong-bing; WANG Ping-fei; ZHANG Xue-man

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Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients

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- Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients
- Journal of Army Medical University Vol. 29, Issue 16, Pages: 1615-1617(2007)
- 作者机构：
  
  四川省达州市中心医院呼吸内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R454;R563.8
- Published：2007，
  
  Published Online：30 August 2007，
- 稿件说明：
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WANG HONG-JUN, LI HONG-BING, WANG PING-FEI, et al. Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients. [J]. Journal of army medical university, 2007, 29(16): 1615-1617.
DOI：

WANG HONG-JUN, LI HONG-BING, WANG PING-FEI, et al. Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients. [J]. Journal of army medical university, 2007, 29(16): 1615-1617. DOI：

摘要

目的观察无创通气（non-invasive positive pressure ventilation

NIPPV）在治疗AECOPD合并Ⅱ型呼吸衰竭患者中的临床疗效。方法治疗组53例AECOPD合并Ⅱ型呼吸衰竭患者在常规治疗的基础上进行NIPPV治疗，对照组53例仅给予常规抗炎、解痉、吸氧等治疗，观察血气指标、心率、血压、呼吸频率及住院时间的变化。结果治疗组和对照组在治疗后动脉血气pH值、PaCO

、PaO

、心率和呼吸频率与治疗前比较均有明显改善。治疗组在降低PaCO

、呼吸频率和提高PaO

方面比对照组效果更明显。结论 NIPPV治疗AECOPD合并Ⅱ型呼吸衰竭能更有效地降低PaCO

、呼吸频率，提高PaO

，减少有创机械通气的几率，缩短住院时间。

Abstract

Objective To observe the clinical effect of non-invasive positive pressure ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease at acute exacerbation phase (AECOPD) combined with typeⅡrespiratory failure. Methods Fifty-three patients of therapeutic group were treated with NIPPV

as well as conventional therapeutic managements

such as antibiotic

pacifying gasp

eliminating phlegm

taking respiratory stimulants

and receiving continual low-flow oxygen. Whereas

53 controls only received conventional intervention. Results There was no

significant difference between the 2 groups before the treatment

but significance was found in pH value

PaCO

PaO

HR and RR in them. The therapeutic group showed significantly improvement in PaCO

RR and PaO

compared with control group. Conclusion NIPPV intervention can effectively lower PaCO

and RR

improve PaO

shorten the course of hospitalization.

关键词

AECOPD呼吸衰竭无创正压通气

Keywords

chronic obstructive pulmonary disease at acute exacerbation phaserespiratory failurenon-invasive positive pressure ventilation

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