Dose effect of low intensity ultrasound on uterine smooth muscle in rats

ZHANG Ying; SUN Jiang-chuan; CHANG Shu-fang; WANG Zhi-biao; WANG Guang-zhen; LIU Ya-min

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Dose effect of low intensity ultrasound on uterine smooth muscle in rats

更新时间：2025-01-15

- Dose effect of low intensity ultrasound on uterine smooth muscle in rats
- Journal of Army Medical University Vol. 29, Issue 16, Pages: 1566-1568(2007)
- 作者机构：
  
  重庆医科大学：医学超声工程研究所, 附属第二医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R322.65;R337.2;R454.3
- Published：2007，
  
  Published Online：30 August 2007，
- 稿件说明：
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ZHANG YING, SUN JIANG-CHUAN, CHANG SHU-FANG, et al. Dose effect of low intensity ultrasound on uterine smooth muscle in rats. [J]. Journal of army medical university, 2007, 29(16): 1566-1568.
DOI：

ZHANG YING, SUN JIANG-CHUAN, CHANG SHU-FANG, et al. Dose effect of low intensity ultrasound on uterine smooth muscle in rats. [J]. Journal of army medical university, 2007, 29(16): 1566-1568. DOI：

摘要

目的通过研究低强度超声对大鼠子宫平滑肌收缩的影响，寻找超声引起子宫收缩的适宜参数。方法利用正交设计的方法，用不同声强、不同辐照时间的超声（频率0.8 MHz

声强1～3 W/cm

）辐照离体大鼠子宫肌条，采用BL-410生物机能实验系统记录子宫平滑肌的收缩情况。结果在相同的频率下，超声辐照时大鼠子宫收缩频率、幅度、张力及子宫活动力均明显高于辐照前（P

0.01）

辐射停止后10 min

子宫收缩基本恢复至辐射前状态；子宫收缩的频率、幅度、张力及活动力在2 W、10 min时达到最大（P

0.05）。结论低强度超声可引发子宫平滑肌收缩，在频率不变的情况下，2 W/cm

辐照10 min是适宜的辐照参数。

Abstract

Objective To study the influence of low intensity ultrasound on the contraction of uterine smooth muscle in rats in order to find suitable exposure parameters of the contraction. Methods The uteri were taken out and irradiated by ultrasound at different intensities and for exposure times (0.8 MHz

1-3 W/cm

) by the ways of orthogonal design. The contraction frequency and amplitude were recorded with BL-410 biological experimental system. Results The contraction frequency

amplitude

tension and activity were significantly increased during ultrasonic irradiation (P

0.01) compared with no irradiation. The increased contraction frequency and amplitude lasted for 10 min

and then the nor

mal contraction pattern was resumed. When the intensity of 2 W/cm

ultrasonic irradiation lasted for 10 min

the contraction frequency

amplitude

tension and contraction activity peaked during 2 W/cm

ultrasonic irradiation for 10 min. Conclusion Low intensity ultrasound can induce uterine smooth muscle contraction in rats. With constant frequency

the suitable parameter is 2 W/cm

ultrasonic irradiation for 10 min.

关键词

低强度超声子宫平滑肌参数

Keywords

low intensity ultrasounduterine smooth muscleparameter

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