Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats

CHEN Xiu-ming; AI Guo-ping; SU Yong-ping; ZHANG Li-long; CHANG Qing

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Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats

更新时间：2025-01-15

- Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats
- Journal of Army Medical University Vol. 29, Issue 16, Pages: 1559-1561(2007)
- 作者机构：
  
  第三军医大学: 西南医院妇产科，军事预防医学院防原医学教研室,全军复合伤研究所,创伤、烧伤与复合伤国家重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R977.12;R331.1;R711.75
- Published：2007，
  
  Published Online：30 August 2007，
- 稿件说明：
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CHEN XIU-MING, AI GUO-PING, SU YONG-PING, et al. Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats. [J]. Journal of army medical university, 2007, 29(16): 1559-1561.
DOI：

CHEN XIU-MING, AI GUO-PING, SU YONG-PING, et al. Effect of a novel isoflavone compound on plasma lipid and cholesterol of ovarectomied rats. [J]. Journal of army medical university, 2007, 29(16): 1559-1561. DOI：

摘要

目的通过观察去势后大鼠的血脂和胆固醇及子宫质量/体质量值的改变，探讨腹腔注入不同剂量的改构异黄酮类化合物（F11）对大鼠的影响。方法 3月龄的SD大鼠，分为假手术组、阴性造模组(造模组)、雌二醇组（E2组）、不同浓度的F11组（低、中、高剂量F11组）；除假手术组外，其余各组均切除双侧卵巢。各组大鼠每日腹腔注射1次，连续用药10周后股动脉放血处死，取血清测定血总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白；称体质量及子宫质量，计算其比值。结果 F11各处理组与造模组比较，大鼠血甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白均有显著变化（P<0.05），而体质量较造模组大鼠下降，子宫质量增加。结论改构后的异黄酮类化合物（F11）具有雌激素活性，可以影响血脂及胆固醇，控制体质量，轻微改善阴道及子宫萎缩。

Abstract

Objective To investigate the effect of a novel isoflavone compound (F11) on the plasma lipid and cholesterol of the ovarectomied rat. Methods Female SD rats at age of 3 months old were randomly divided into 6 groups

that is

sham operation group (Sham)

normal saline group (2 ml/d)

estradiol group (E2

50 μg·kg

-1

·d

-1

)

and 3 F11 groups (15

150 mg·kg

-1

·d

-1

). Besides the Sham group

the ovary of the rats from other groups were resected

and received the injection as above mentioned. All rats were killed 10 weeks later

and their plasma lipid

total cholesterol

LDL

HDL

and body weight and uterine weight were measured.

Results The plasma lipid

total cholesterol

LDL

HDL were significantly different in normal saline group and 4 treatment group (P

0.05). Rats of normal saline group had elevated body weight and decreased uterine weight in comparison with sham group. Conclusion The novel compound F11 can decrease plasma lipid of ovarectomied rat

control body weight and resist the change of uterine.

关键词

去势法动物模型血脂体质量

Keywords

ovarectomyanimal modelplasma lipidbody weight

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