HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population

TAN Wen-ting; DENG Guo-hong; WANG Yu-ming; DAN Yun-jie; KUANG Xue-mei

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HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population

更新时间：2025-01-15

- HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population
- Journal of Army Medical University Vol. 30, Issue 24, Pages: 2321-2323(2008)
- 作者机构：
  
  第三军医大学西南医院全军感染病研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R181.33;R373.21;R512.620.1
- Published：2008，
  
  Published Online：30 December 2008，
- 稿件说明：
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TAN WEN-TING, DENG GUO-HONG, WANG YU-MING, et al. HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population. [J]. Journal of army medical university, 2008, 30(24): 2321-2323.
DOI：

TAN WEN-TING, DENG GUO-HONG, WANG YU-MING, et al. HBV genotype distribution and its influences on progression of HBV-related chronic liver disease in Chongqing population. [J]. Journal of army medical university, 2008, 30(24): 2321-2323. DOI：

摘要

目的调研重庆地区乙型肝炎病毒（hepatitis B virus

HBV）基因型构成，探讨HBV基因型与乙型肝炎疾病进程的相关性。方法用SSP-PCR法对360例HBV DNA阳性患者HBV基因分型，采用多因素Logistic回归分析HBV基因型与疾病表型的相关性。结果本回顾性研究人群中，HBV-B型占45.6％，HBV-C型占53.9%，分型失败0.5%。随着疾病从慢性乙型肝炎到肝硬化、原发性肝细胞癌的进展，C型HBV所占比例显著上升（χ

=23.368，

0.001）。Logistic回归分析显示HBV基因型是HBV感染者罹患肝癌的独立风险因素(

=3.2

=0.01)。B、C基因型患者的HBV DNA水平和HBeAg阳性率无显著差异(

>0.05)。结论重庆地区HBV基因型以B、C型为主，C型HBV更易导致严重的肝病，HBV基因型是影响疾病进程的重要因素。

Abstract

Objective To study the distribution of hepatitis B virus (HBV) genotypes in Chongqing city and its clinical influences. Methods The genotype of HBV was detected by SSP-PCR while the HBV DNA by FQ-PCR and HBeAg by ELISA. Results Among 360 HBV DNA positive patients who have lived in Chongqing

the prevalence of HBV/B and C was 45.6% and 53.9%

respectively. The rate of genotype C increased with the progression of chronic liver disease from chronic hepatitis B (CHB) (42.4%)

liver cirrhosis (LC) (67.4%) to hepatocellular carcinoma (HCC) (74.0%)

with significant differences among these groups (χ

=23.368

0.01). Logistic regression analysis indicated that HBV genotype is an independent risk factor for HBV-related HCC (

=3.2

=0.01). No significant difference was found in the positive rate of HBeAg or the serum level of HBV DNA among the patients of genotype B and C (

>0.05)

even though the positive rate of HBeAg was slightly higher in the patients of genotype B (40.9%) than that of genotype C (36.1%). Conclusion Genotype C and B are the dominant genotypes for Chongqing population. The damage to liver induced by genotype C is more severe than that by genotype B. HBV genotype plays a role in the progression of serious HBV-related liver disease.

关键词

肝炎病毒乙型基因型疾病表型HBV DNA

Keywords

hepatitis virustype Bgenotypedisease phenotypeHBV DNA

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