Prediction of B cell epitope for Eppin antigen

LI Jin-tao; CHEN Zheng-qiong; LIANG Zhi-qing; YAN Ping; HE Wei; WU Yu-zhang

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Prediction of B cell epitope for Eppin antigen

更新时间：2025-01-15

- Prediction of B cell epitope for Eppin antigen
- Journal of Army Medical University Vol. 30, Issue 24, Pages: 2254-2257(2008)
- 作者机构：
  
  第三军医大学：基础医学部全军免疫学研究所，西南医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R341;R392.2;R392.7
- Published：2008，
  
  Published Online：30 December 2008，
- 稿件说明：
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LI JIN-TAO, CHEN ZHENG-QIONG, LIANG ZHI-QING, et al. Prediction of B cell epitope for Eppin antigen. [J]. Journal of army medical university, 2008, 30(24): 2254-2257.
DOI：

LI JIN-TAO, CHEN ZHENG-QIONG, LIANG ZHI-QING, et al. Prediction of B cell epitope for Eppin antigen. [J]. Journal of army medical university, 2008, 30(24): 2254-2257. DOI：

摘要

目的分析Eppin抗原的二级结构并预测其B细胞表位。方法联合运用多种方法对Eppin的二级结构和表面特性，如亲水性、理化性质、可及性、免疫原性和可塑性等方面进行分析，预测其抗原表位。结果 Eppin存在多个潜在的抗原表位位点，可能的蛋白质抗原表位区域：14～23，30～44，48～54，56～68，78～85，97～106，109～116，125～132。体外实验证明，所预测抗原表位区域基本能与免疫抗血清发生抗原特异性反应。结论应用多参数成功预测了Eppin抗原的B细胞表位。

Abstract

Objective To predict the B cell epitope for Eppin antigen. Methods The secondary structure and surface properties of Eppin

such as physical and chemical properties

hydrophilicity

accessibility

antigenicity and plasticity

were analyzed by a variety of methods. Results Many distinct antigenic epitopes in Eppin were identified by computation

the possible location of which is in the regions of 14-23

30-44

48-54

56-68

78-85

97-106

109-116

and 125-132. Conclusion The B cell epitope for Eppin is successfully predicted.

关键词

Eppin抗原B 细胞表位

Keywords

Eppin antigenB cellepitope

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Related Institution

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Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention

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