Preparation and <em>in vitro</em> release feature of a scleral implant containing triamcinolone acetonide acetate

HU Lei; LIU Song-qing; GUO Wei; Dai Qing; LIU Yun-jia

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Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate

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- Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate
- Journal of Army Medical University Vol. 31, Issue 8, Pages: 706-709(2009)
- 作者机构：
  
  第三军医大学：西南医院药学部,学员旅12队
- 作者简介：
- 基金信息：
- DOI：
  CLC： R943;R944.9;R988.1
- Published：2009，
  
  Published Online：30 April 2009，
- 稿件说明：
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HU LEI, LIU SONG-QING, GUO WEI, et al. Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate. [J]. Journal of army medical university, 2009, 31(8): 706-709.
DOI：

HU LEI, LIU SONG-QING, GUO WEI, et al. Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate. [J]. Journal of army medical university, 2009, 31(8): 706-709. DOI：

摘要

目的制备醋酸曲安奈德（triamcinolone-acetonide-acetate

TAA）-聚乳酸（polylactic acid

PLA）植入剂（Implant），考察醋酸曲安奈德植入剂的体外释药特性。方法采用熔融-挤出法制备TAA-PLA 植入剂，高效液相色谱法测定TAA含量，绘制体外释放曲线。结果制得的植入剂为直径0.8 mm，长约8 mm，质量约8 mg的白色柱状物，其中TAA的载药量为30%，体外释放速率平稳且缓慢，第30天时TAA的累积释放率为75.84%，药物体外释放符合Higuchi方程 Q = 0.137×(

-0.752)

1/2

。结论所制备的TAA-PLA 植入剂对药物TAA有明显的缓释效果，且在体内可生物降解，毒副作用小，有望成为TAA的眼部新型给药制剂。

Abstract

Objective To prepare a biodegradable sckeral implant containing triamcinolone-acetonide-acetate (TAA) and polylactic acid (PLA) and investigate its release

in vitro

. Methods The TAA-PLA implant was prepared by melt-extrude technique. The drug release of TAA

in vitro

was determined by high performance liquid chromatography (HPLC). Results The implant was white pillar with 8 mm in length

8 mg in weight

and 0.8 mm in diameter. The drug loading was 30%. The drug was released at a steady and slow rate. Its accumulation release rate is 75.84% on the 30th day. Drug release profile

in vitro

was in accordance

with Higuchi equation Q=0.137 (

-0.752)

1/2

. Conclusion A sleral implant containing TAA-PLA is prepared

which has the evident feature in delaying the release of TAA and is biological degradable. It might be a novel vehicle for the topical use of TAA.

关键词

聚乳酸醋酸曲安奈德眼色素层炎巩膜植入剂

Keywords

polylactic acidtriamcinolone acetonide acetateuveitisscleral implant

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Department of General Surgery, Children’s Hospital, Chongqing Medical University

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Preparation and in vitro release feature of a scleral implant containing triamcinolone acetonide acetate

DOI：

摘要

Abstract

关键词

Keywords

references