Relationship between endothelin-1 gene polymorphisms and essential hypertension

HANG Li-wei; WU Zhi-hong; WANG Zhen; DOU Gui-wang; CAI Jia-chun; ZHOU Jian-zhong

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Relationship between endothelin-1 gene polymorphisms and essential hypertension

更新时间：2025-01-15

- Relationship between endothelin-1 gene polymorphisms and essential hypertension
- Journal of Army Medical University Vol. 31, Issue 8, Pages: 684-688(2009)
- 作者机构：
  
  重庆医科大学：附属第一医院心血管内科,公共卫生学院流行病学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R181.33;R394.3;R544.102
- Published：2009，
  
  Published Online：30 April 2009，
- 稿件说明：
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HANG LI-WEI, WU ZHI-HONG, WANG ZHEN, et al. Relationship between endothelin-1 gene polymorphisms and essential hypertension. [J]. Journal of army medical university, 2009, 31(8): 684-688.
DOI：

HANG LI-WEI, WU ZHI-HONG, WANG ZHEN, et al. Relationship between endothelin-1 gene polymorphisms and essential hypertension. [J]. Journal of army medical university, 2009, 31(8): 684-688. DOI：

摘要

目的探讨重庆地区人群血管内皮素-1（endothelin-1

ET-1）基因Lys198Asn、

Taq

Ⅰ酶切位点基因多态性与原发性高血压(essential hypertension

EH)的关系。方法运用序列特异引物聚合酶链反应(sequence specific primer polymerase chain reaction

SSP-PCR)和限制性内切酶片段长度多态性(restriction fragment length polymorphism

RFLP)方法分析86例EH患者和138例非EH患者的Lys198Asn和

Taq

Ⅰ 2个位点基因多态性。结果体质量指数（body mass index

BMI）＜25 kg/m

人群中高血压组的

Taq

Ⅰ酶切位点基因型分布频率为: GG型26例（72.2％），GA+AA型10例（27.8％）；对照组: GG型28例（50.0％）

GA+AA型28例（50.0％）。Logistic回归分析显示BMI＜25 kg/m

人群中携带GG基因型(

Taq

Ⅰ酶切位点)的患者发生高血压的风险增加（

=0.037

=2.597）。线性回归结果显示收缩压(SBP)在BMI＜25 kg/m

人群的GG型平均值为145.06，显著高于GA+AA型平均值131.97（

=0.018)。结论在BMI＜25 kg/m

人群中

Taq

Ⅰ酶切位点GG基因型更易导致SBP升高，GG基因型可能是BMI较小人群血压升高的一个危险因素。

Abstract

Objective To investigate the relationship between Lys198Asn and

Taq

Ⅰ polymorphisms of endothelin-1 gene and essential hypertension in Chongqing residents. Methods Polymorphisms of Lys198Asn and

Taq

Ⅰ were detected in the blood samples from 86 patients with essential

hypertension (HT) and 138 normotensive controls (NT) by sequence specific primer-polymerase chain reaction (SSP-PCR) and PCR-restriction fragment length polymorphism (PCR-RFLP). Results In the BMI

25 kg/m

subjects

the frequency of GG and GA+AA of

Taq

Ⅰ was 26 (72.2%) and 10 (27.8%) respectively in hypertensive group

28 (50.0%) and 28 (50.0%) respectively in normotensive group. Logistic regression model analysis showed that the GG carriers of

Taq

Ⅰ had a significant high risk to develop hypertension (

=0.037

=2.597）in BMI

25 kg/m

subjects. The liner regression model analysis demonstrated that there was a significant difference in systolic blood pressure (SBP) between GG and GA+AA in BMI

25 kg/m

subjects (

=0.018). SBP of the GG carriers (145.06 mmHg) were 13.09 mmHg higher than those of GA+AA carriers (131.97 mmHg). Conclusion Among the BMI

25 kg/m

 subjects

those with GG carriers of

Taq

Ⅰ might be prone to have higher SBP. The GG genotype might be a risk factor for hypertension in normoweight subjects.

关键词

内皮素-1基因多态性原发性高血压

Keywords

endothelin-1 genepolymorphismessential hypertension

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