Objective   To investigate the effects of intensive insulin therapy on the serum proteins in severe trauma patients.    Methods   Eighty severe trauma patients were randomly divided into the intensive insulin therapy group (

n

=40) and routine therapy group (

n

=40). The insulin pump was given to the first group to keep the blood glucose in the range of 6 to 8 mmol/L and routine treatment was carried out at the same time. The patients of the routine therapy group had similar calorie intake as insulin group did. The values of albumin (AL)

prealbumin (PA)

retinol-binding protein (RBP) and fructosamine (FMN) in serum were assayed b

efore intensive insulin therapy and at day 1

3

7

10

14 and 21 after therapy.    Results   The levels of serum proteins were obviously decreased at early stage and restored at later stage after severe trauma. But the levels of AL at day 10

PA at day 7

RBP at day 3 after therapy in the intensive insulin therapy group were significantly improved as compared with routine therapy group. The levels of FMN at day 14 after therapy in the intensive insulin therapy group were significantly lower than those in routine therapy group（

P

<

0.05）.    Conclusion   Intensive insulin therapy strictly controls the blood sugar of severe trauma patients

which can effectively restore serum proteins and improve the status of nutrition.