Quantitative analysis on developmental morphologic changes on mandibles of Apert syndrome mice

DU Xiao-lan; CHEN Zhi; YIN Liang-jun; SU Nan; HE Qi-fen; DUAN Ya-qi; CHEN Lin

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Quantitative analysis on developmental morphologic changes on mandibles of Apert syndrome mice

更新时间：2025-01-15

- Quantitative analysis on developmental morphologic changes on mandibles of Apert syndrome mice
- Journal of Army Medical University Vol. 31, Issue 17, Pages: 1625-1628(2009)
- 作者机构：
  
  1. 第三军医大学大坪医院野战外科研究所全军战创伤中心，创伤、烧伤与复合伤国家重点实验室
  2. 四川省绵阳市疾病预防控制中心微生物所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R782.23;R195.2;R323.1
- Published：2009，
  
  Published Online：15 September 2009，
- 稿件说明：
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DU XIAO-LAN, CHEN ZHI, YIN LIANG-JUN, et al. Quantitative analysis on developmental morphologic changes on mandibles of Apert syndrome mice. [J]. Journal of army medical university, 2009, 31(17): 1625-1628.
DOI：

DU XIAO-LAN, CHEN ZHI, YIN LIANG-JUN, et al. Quantitative analysis on developmental morphologic changes on mandibles of Apert syndrome mice. [J]. Journal of army medical university, 2009, 31(17): 1625-1628. DOI：

摘要

目的比较分析FGFR2 Ser252Trp突变小鼠（mutant

Mu）下颌骨和同窝对照野生型小鼠(wild type

WT)下颌骨的形状和发育差异性。方法采用三维坐标测量仪检测下颌骨11个标记点的三维坐标值，用欧几里德几何距离矩阵法（euclidean distance matrix analysis

EDMA）对突变小鼠和对照小鼠下颌骨进行形状和发育分析。结果 4周时FGFR2 Ser252Trp突变小鼠下颌骨形状与同窝对照组相比整体有所缩小，但无统计学差异（

>0.05）；8周时突变小鼠下颌骨形状缩小具有统计学差异（

0.05），主要表现在冠状突和下颌角缩小并沿前后方向向前缩进，随着年龄的增加下颌角的缩进更明显。结论 FGFR2 Ser252Trp点突变对小鼠下颌骨形状产生缩短畸形的影响，随着年龄的增加缩短影响有所加重。

Abstract

Objective To compare and analyze the morphologic and growth difference between the mandibles of the mouse carrying Ser252Trp mutation in fibroblast growth factor receptor (FGFR2) which was regarded as a model for human Apert syndrome

and of their wild type controls. Methods The 3-D coordinate data of 11 landmarks of the mandible were collected by a 3-D coordinate measuring machine. Data were analyzed using Euclidean distance matrix analysis (EDMA) to quantitatively compare the morphologic and growth difference between the mandibles of mutants and their controls. Results At 4 weeks old

the mutants’ mandible was smaller than their wild

type control

and there was no statistical difference between them (

>0.05). The mandible was much smaller in the mutants than their wild type controls

with a statistical difference when they were 8 weeks old (

0.05). The major abnormality in the mutants was the anteriorly displaced coronoid process and mandibular angle along anterio-posterior axis

which becomes more severe with age. Conclusion The reducing of the mutants’ mandibles becomes more severe with age.

关键词

2型成纤维细胞生长因子受体小鼠模型Apert综合征下颌骨形状发育EDMA

Keywords

fibroblast growth factor receptor 2mouse modelApert syndromemandibleEuclidean distance matrix analysis

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Related Institution

State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University

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Research Center of Molecular Medicine and Cancer, Center of Biochemistry and Molecular Biology, Department of Pathophysiology, College of Basic Medical Sciences, Chongqing Medical University

Department of Laboratory Animal Science, College of Basic Medical Sciences, Army Medical University (Third Military Medical University)

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