Objective  To study the serum levels of proinsulin (PI)

insulin (INS)

proamylin (PA) and amylin (AMY) in abnormal glucose metabolism individuals and to explore the relationship between PI and insulin resistance (IR) and between PA and islet beta cell function. Methods  Totally 79 subjects who received Oral glucose tolerance test (OGTT) and  insulin release test in our department from March to May 2008 were divided into 4 groups according to the results of OGTT

that is

normal group

impaired glucose regulation (IGR) group，T2DM 1 [fas

ting blood-glucose(FBG)

<

10 mmol/L

]

group

and T2DM 2 (FBG>15 mmol/L) group. All subjects underwent examination of anthropometry and serum bio-chemical indicators

HOMA-IR and HOMA-B were calculated. Results  No significant difference was found in the serum levels of PI or AMY among the 4 groups

but the level of PA

PI/INS and PA/AMY among the 4 groups did have significant differences (

P

<

0.05). HOMA-IR was significantly influenced by PI and PI/INS (

P

<

0.01) and HOMA-B was significantly influenced by PA and PA/AMY (

P

<

0.01). Conclusion  Pro-insulin may be very important in the process of IR

while pro-amylin may exert considerable effect on islet β cells’ dysfunction.