Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits

Tan Qunyou; Xiong Huarong; Wang Rui; Li Yi; Zhang Jingqing

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Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits

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- Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits
- Journal of Army Medical University Vol. 33, Issue 5, Pages: 511-514(2011)
- 作者机构：
  
  1. 第三军医大学大坪医院野战外科研究所胸外科
  2. 重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R971.92;R961;R969.1
- Published：2011，
  
  Published Online：15 March 2011，
- 稿件说明：
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TAN QUNYOU, XIONG HUARONG, WANG RUI, et al. Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits. [J]. Journal of army medical university, 2011, 33(5): 511-514.
DOI：

TAN QUNYOU, XIONG HUARONG, WANG RUI, et al. Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits. [J]. Journal of army medical university, 2011, 33(5): 511-514. DOI：

摘要

目的研究溴吡斯的明缓释片与其普通片在兔体内的药代动力学与相对生物利用度。方法 6只新西兰兔随机分成2组，采用自身交叉对照实验，单剂量口服溴吡斯的明缓释片或普通片后，采用高效液相色谱法测定血浆中溴吡斯的明浓度，计算药动学参数和相对生物利用度。结果溴吡斯的明普通片与缓释片给药后，药动学参数如下：t

max

分别为2 h和 4 h；C

max

分别为（17.944±0.991）mg/L和（15.442±0.215）mg/L；AUC

0-∞

分别为（201.956±4.623）mg/(h·L)和（200.557±3.357）mg/(h·L)；与普通片相比，缓释片的相对生物利用度为102.89%。结论溴吡斯的明缓释片有明显的缓释效果，与普通片生物等效。

Abstract

Objective To study the pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets and conventional tablets in rabbits. Methods Six New Zealand rabbits were randomly and evenly divided into two groups. Based on the self-crossover control experiment

the rabbits were subjected to single-dose oral administration of pyridostigmine bromide sustained-release tablets and conventional tablets. The pyridostigmine bromide concentrations in the plasma of rabbits were measured by high-performance liquid chromatography

based on which the pharmacokinetic parameters and relative bioavailability were calculated. Results

After delivery

pyridostigmine bromide sustained-release tablets and conventional tablets had the following pharmacokinetic parameters: t

max

= 2 h and 4 h; C

max

= 17.944 0.991 mg/L and 15.442±0.215 mg/L; AUC

0-∞

= 201.956±4.623 mg/(h·L) and 200.557±3.357 mg/(h·L). When compared with conventional tablets

sustained-release tablets had relative bioavailability of 102.89%. Conclusion Pyridostigmine bromide sustained-release tablets have an obvious sustained-release effect

and are bioequivalent to conventional tablets.

关键词

溴吡斯的明缓释片药代动力学相对生物利用度

Keywords

pyridostigmine bromide sustained-release tabletspharmacokineticsrelative bioavailability

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