mRNA and protein expression of chloride intracellular channel 1 in colon cancer and clinical significance

Wang Pan; Zhang Chao; Liu Tao; Cui Hao

您当前的位置：

首页 >

文章列表页 >

mRNA and protein expression of chloride intracellular channel 1 in colon cancer and clinical significance

更新时间：2025-01-15

- mRNA and protein expression of chloride intracellular channel 1 in colon cancer and clinical significance
- Journal of Army Medical University Vol. 33, Issue 22, Pages: 2407-2409(2011)
- 作者机构：
  
  第三军医大学西南医院全军普通外科中心，微创胃肠外科中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R341;R735.35;R730.23
- Published：2011，
  
  Published Online：30 November 2011，
- 稿件说明：
移动端阅览
WANG PAN, ZHANG CHAO, LIU TAO, et al. mRNA and protein expression of chloride intracellular channel 1 in colon cancer and clinical significance. [J]. Journal of army medical university, 2011, 33(22): 2407-2409.
DOI：

WANG PAN, ZHANG CHAO, LIU TAO, et al. mRNA and protein expression of chloride intracellular channel 1 in colon cancer and clinical significance. [J]. Journal of army medical university, 2011, 33(22): 2407-2409. DOI：

摘要

目的探讨氯离子通道-1(chloride intracellular channel 1，CLIC-1) mRNA及蛋白在结肠癌中的表达及其临床意义。方法采用RT-PCR和免疫组化检测2011年1-6月本院手术切除的54例结肠癌和相应癌旁组织中CLIC-1 mRNA及蛋白的表达，分析其与临床病理特征的关系。结果结肠癌组织中的CLIC-1 mRNA表达水平高于癌旁组织[（0.658±0.043）

(0.281±0.027)，

0.05

]

，CLIC-1蛋白表达与浸润程度、有无淋巴结转移和TNM分期比较差异有统计学意义（

0.05，

0.01），而与患者的年龄、性别、肿瘤直径、原发部位、分化程度方面比较差异无统计学意义（

>0.05）。结论 CLIC-1在结肠癌中的表达明显升高，在结肠癌的进展中可能有一定作用。

Abstract

Objective To investigate the expression of chloride intracellular channel 1 (CLIC-1) in colon cancer and its clinical significance. Methods Expression of CLIC-1 mRNA and protein were detected by reverse transcription PCR (RT-PCR) and immunohistochemical staining in 54 tissue samples of colon carcinoma and corresponding para-carcinoma tissues collected in our hospital from January to June 2011

respectively. Correlation of CLIC-1 expression and clinicopathologic features was analyzed. Results CLIC-1 mRNA and protein expression in colon cancer tissues was signif

icantly higher than that in corresponding para-carcinoma tissues (

0.05

respectively). Significant differences were found among invasion degree (

0.05)

lymph node metastasis (

0.05) and TNM stage (

0.01) of the patients with CLIC-1 protein expression. However

there was no significant difference among age

sex and size

position and differentiation of the patients with CLIC-1 protein expression (

>0.05

respectively). Conclusion CLIC-1 is highly expressed in colon cancer

and may play a certain role in progression of colon cancer.

关键词

CLIC-1结肠肿瘤RT-PCR免疫组化

Keywords

chloride intracellular channel 1colon cancerRT-PCRimmunohistochemistry

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Expression of up-regulated gene-4 in colon cancer and its clinicopathologic significance

Expression and clinical significance of B cell translocation gene 2 in primary hepatocellular carcinoma

Related Author

Cui Hao

Zhang Chao

Liu Tao

Wang Pan

Xu Jianhua

LIN Yingxin1

ZHANG Yuehua2

ZHANG Ganmei2

Related Institution

Department of General Surgery, Southwest Hospital, Third Military Medical University

Department of Breast Oncology, 2Department of Pathology, the Affiliated Foshan Hospital of Sun Yat-sen University

Department of Periodontics, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Stomatological Hospital of Chongqing Medical Univevrsity

Department of Urology, Hunan Cancer Hospital, Affiliated Cancer Hospital to Xiangya School of Medicine of Central South University

Cancer Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University

⁰