Objective      To explore the influence of Bushen Guchi Bolus on the alveolar bone reconstruction of rats with experimental periodontitis

and to investigate the treatment mechanism of the drug.       Methods      The model of experimental periodontitis were established by means of steel wire

high-carbohydrate diet and periopathogens inoculation in rats.  Then Bushen Guchi Bolus was given to rats of treatment group at a

dose of 0.8 g/(kg·d) by gastric injection for 30 d

and 10 ml/(kg·d) normal saline was give to rats of normal control and model group for same period. All rats were killed at then end of treatment. The contents of osteocalcin (OCN) and pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen (ICTP) in the serum were observed by radioimmunoassay (RIA). Micro-CT and software digitized specimens were reconstructed three-dimensionally for parameter assessment of alveolar bone (including bone volume /total volume

trabecular number

and trabecular separation).       Results      Rat experimental periodontitis models were successfully established by steel wire

high-carbohydrate diet and periopathogens inoculation. After 30 days’ treatment of Bushen Guchi Bolus

the level of OCN and ICTP in the serum were decreased in treatment group (0.859 1±0.156 9 and 2.038 6±0.407 5

P

<

0.05)

compared with model control group (1.806 4±0.258 5 and 3.056 0±0.461 5). After treatment

BV/TV of alveolar bone had distinct improvement (0.304 1±0.010 0

P

<

0.05)

and Tb.N showed a trend of increase in the treatment group (3.124 4±0.100 0

P

>0.05). In addition

Tb.Sp in the treatment group (0.575 1±0.020 0) was inferior to that of the model group （0.611 0±0.030 00

P

<

0.05）.       Conclusion      Bushen Guchi Bolus improves alveolar bone reconstruction of rats with experimental periodontitis.