Probiotics as supplement for early enteral nutrition decreases infection in severe brain injury

Xiong Xiaowei; Zhou Yiyan; Dong Li; Zhu Jingci

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Probiotics as supplement for early enteral nutrition decreases infection in severe brain injury

更新时间：2025-01-15

- Probiotics as supplement for early enteral nutrition decreases infection in severe brain injury
- Journal of Army Medical University Vol. 35, Issue 6, Pages: 536-539(2013)
- 作者机构：
  
  1. 第三军医大学护理学院基础护理学教研室
  2. 重庆市急救中心护理部
- 作者简介：
- 基金信息：
- DOI：
  CLC： R630.1;R651.15;R459.3
- Published：2013，
  
  Published Online：30 March 2013，
- 稿件说明：
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XIONG XIAOWEI, ZHOU YIYAN, DONG LI, et al. Probiotics as supplement for early enteral nutrition decreases infection in severe brain injury. [J]. Journal of army medical university, 2013, 35(6): 536-539.
DOI：

XIONG XIAOWEI, ZHOU YIYAN, DONG LI, et al. Probiotics as supplement for early enteral nutrition decreases infection in severe brain injury. [J]. Journal of army medical university, 2013, 35(6): 536-539. DOI：

摘要

目的观察益生菌联合早期肠内营养对重型颅脑损伤患者感染的影响。方法选取重型颅脑损伤患者38例，按随机数字表分为研究组（17例）和对照组（21例）。2组患者均在入院后24～72 h内开始经鼻胃管行肠内营养，研究组在肠内营养基础上添加益生菌。于肠内营养开始后1、4、7、15 d晨空腹抽血监测白细胞、淋巴细胞、C-反应蛋白等指标，记录患者感染发生时间、严重程度，观察患者预后情况，比较ICU住院天数和GCS、SOFA、APACHEⅡ评分。结果研究组白细胞计数在营养后7 d显著低于对照组（

0.05），C-反应蛋白在15 d显著低于对照组（

0.05），而淋巴细胞计数在各时相点两组差异均无统计学意义（

>0.05）。研究组总感染发生率、肺部感染发生率也显著低于对照组（

0.05），其ICU住院天数明显降低（

0.05）。在营养第15天，研究组GCS评分显著高于对照组（

0.05）。结论与单纯早期肠内营养相比，添加益生菌能更好地降低重型颅脑损伤患者的感染发生率，缩短ICU住院天数，改善患者的预后。

Abstract

Objective To determine the effect of probiotics as supplement in early enteral nutrition on infection status of patients with severe brain injury. Methods Thirty-eight patients with identified severe brain injury and Glasgow coma scale (GCS) of 5 to 8 for over 12 h who admitted in Chongqing Center of Emergency from September 2011 to July 2012 were enrolled in this study. They were randomized into study group (

=17) and control group (

=21)

with no signifi

cant difference in age

GCS score

sequential organ failure assessment (SOFA)

and acute physiology and chronic health evaluation (APACHE Ⅱ). All patients received enteral nutrition

via

nasogastric tube within 24-72 h following admission

and those from the former group was supported with probiotics in the nutrition. In 1

7 and 15 d after enteral nutrition

fasting blood samples were collected for the counts of leukocyte and lymphocyte

and levels of C-reactive protein (CRP) and other indicators. The infection time and severity

ICU time

GCS

SOFA

and APACHEⅡscore during were recorded and compared in 2 groups. Results The study group had a lower count of leukocytes and level of CRP than control group on day 7 (

0.05)

and lower level of CRP on day 15 (

0.05). However

there was no difference in terms of lymphocyte in each time point（

>0.05）. The incidences of total infection and pulmonary infection rate were significantly lower in study group than in control group (

0.05). The hospitalization time was also shorter in the form than in the later group (

0.05). The former group had a higher GCS scores on day 15 compared with the later group（

0.05）. Conclusion Compared with early enteral nutrition

supplement of probiotics lowers infectious rate

shortens ICU time and promotes prognosis in patients with severe brain injury.

关键词

重型颅脑损伤益生菌早期肠内营养感染发生率

Keywords

severe brain injuryprobioticsearly enteral nutritioninfectious rate

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Related Institution

Department of Gastroenterology, Quanzhou First Hospital

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