Objective      To investigate the value of clinical pulmonary infection score (CPIS score) and the adjusted score of systemic inflammatory response syndrome (ASS score) in severe craniocerebral injury secondary infection.       Methods      A total of 103 patients with severely craniocerebral injury who were admitted in our department from January 2009 to January 20

11 were recruited in this study. CPIS score and ASS score were used to evaluate the patients. The indexes of endpoints for prognosis were ICU stay time

hospitalization time and infection control time. Hospital mortality was the primary outcome endpoint. Receiver operating characteristic curve(ROC) was plotted to determine the predictive value of the 2 scale system.       Results      The dead group had higher CPIS score (

Z

=3.444

P

<

0.01) and ASS score (

t

=6.26

P

<

0.01) than the survivors. The ASS score of the survivors was positively correlated with the ICU stay time

hospitalization time and the infection control time (

r

=0.695

P

<

0.01;

r

=0.725

P

<

0.01;

r

=0.707

P

<

0.01). The area under curve (AUC) was 0.835 for CPIS score

and 0.836 for ASS score

indicating that both of the scores had a good calibration to predict mortality in the patients.       Conclusion      Both CPIS score and ASS score have a good calibration for predicting mortality in patients of severe craniocerebral injury secondary infection. The scores can quantitatively evaluate these patients

and are of great value to carry out scientific and accurate treatment.