Objective       To study the clinical characteristics of sporadic Creutzfeldt-Jakob disease (sCJD) in China.       Methods       The records of sCJD patients in our hospital from 2006 to 2012 and the literatures in China Biological Medicine Database (CBM) and China National Knowledge Infrastructure (CNKI) from 1990 to 2012 were collected. The demographic data

clinical manifestations and laboratory findings of patients with sCJD were analyzed.       Results       Of the total 236 cases

93 had integral data

including 7 from our hospital and 86 from literature. There were 127 males and 109 females

with a mean age of onsetting in 57.5

The cardinal symptoms included dementia (93.3%)

myoclonus (76.1%)

extrapyramidal symptoms (70.6%)

etc. Head magnetic resonance imaging (MRI) was performed in 195 cases. Diffusion-weighted imaging (DWI) of 92 cases showed abnormal hyperintensity in cerebral cortex and basal ganglia. A total of 190 cases had electroencephalogram (EEG) examination. Periodic sharp wave complexes (PSWC) were observed in 171 cases. 14-3-3 protein was found positive in cerebrospinal fluid (CSF) in 41 cases. Pathological examination of the brain tissues showed pathological changes of sCJD in 83 cases.       Conclusion       Consistent with dementia

myoclonus and extrapyramidal performance are the main symptoms of sCJD. The clinical diagnosis of sCJD is not difficult by combining cardinal symptoms with DWI

EEG and 14-3-3 protein.