Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance

Luo Xiaoli; Tan Wenting; Zhou Yuan; Dan Yunjie; Liu Nana; Guo Hong; Deng Guohong

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Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance

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- Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance
- Journal of Army Medical University Vol. 36, Issue 6, Pages: 564-567(2014)
- 作者机构：
  
  1. 第三军医大学西南医院全军感染病研究所，感染病研究重庆市重点实验室
  2. 第三军医大学新桥医院消化内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R373.21;R735.7;R730.23
- Published：2014，
  
  Published Online：30 March 2014，
- 稿件说明：
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LUO XIAOLI, TAN WENTING, ZHOU YUAN, et al. Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance. [J]. Journal of army medical university, 2014, 36(6): 564-567.
DOI：

LUO XIAOLI, TAN WENTING, ZHOU YUAN, et al. Expression of estrogen receptors α and β in hepatitis B virus-related hepatocellular carcinoma and clinical significance. [J]. Journal of army medical university, 2014, 36(6): 564-567. DOI：

摘要

目的探讨雌激素受体（estrogen receptor，ER）α及β在乙型肝炎病毒（hepatitis B vrius，HBV）相关肝细胞癌（hepatocellular carcinoma，HCC）组织中的表达水平及其与临床病理特征的关系。方法收集组织学病理诊断为肝细胞癌，且为慢性乙型肝炎的28例患者的肝癌组织及其相关临床资料，采用免疫组化EnVision法检测ERα和ERβ的表达，分析其与临床病理特点的关系。结果 ERα及ERβ在HBV相关HCC组织中表达以细胞质为主，其阳性表达率分别为35.7%（10/28）和46.4%（13/28）。其中ERα的阳性表达与患者肿瘤大小及TNM分期有关，肿瘤直径≤5 cm的患者表达率高于肿瘤直径＞5 cm的患者（60.0%

7.7%，

=0.006），TNM分期Ⅰ～Ⅱ期患者的表达率明显高于Ⅲ～Ⅳ期的患者（60.0%

16.7%，

=0.011）。ERβ的表达与患者的性别、年龄、肿瘤大小、肿瘤分化程度、TNM分期、结节多少及血清AFP水平无关。结论 ER在HBV相关HCC中存在差异表达，且以细胞质表达为主，其与HCC的临床病理特点有关。

Abstract

Objective To evaluate estrogen receptors (ERs) α and β expression in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in China and their relationship with clinical and pathological characteristics. Methods Expression of ERα and ERβ in 28 cases of HBV-related HCC was detected by immunohistochemistry technique EnVision method. ERα and ERβ relationship with the clinical and pathological characteristics of HBV-related HCC was analyz

ed statistically. Results Both ERα and ERβ were expressed in the cytoplasm. The positive expression rate of ERα and ERβ was 35.7% (10/28) and 46.4% (13/28)

respectively. There was correlation between ERα expression and tumor diameter and TNM stage. Higher ERα expression was found in tumor with diameter ≤5 cm than in tumor with diameter >5 cm (60.0%

7.7%

=0.006)

as well as in tumor with TNM stage Ⅰ to Ⅱ than in tumor with TNM stage Ⅲ to Ⅳ (60.0%

16.7%

=0.011). ERβ expression displayed no significant association with age

sex

tumor size

pathologic subtype

TNM stage

nodule number and serum AFP level. Conclusion ERs expression has differences in HBV-related HCC and is associated with the clinical pathological characteristics of HCC.

关键词

肝细胞癌肝炎病毒，乙型雌激素受体α雌激素受体β

Keywords

hepatocellular carcinomaHBVestrogen receptor αestrogen receptor β

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