Preparation and evaluation of self-microemulsifying drug delivery system for artemether <em>in vitro</em>

Zhang Yahong; Lin Fengyun; Qiu Yanchuan; Zhu Zhaojing

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Preparation and evaluation of self-microemulsifying drug delivery system for artemether in vitro

更新时间：2025-01-15

- Preparation and evaluation of self-microemulsifying drug delivery system for artemether in vitro
- Journal of Army Medical University Vol. 35, Issue 21, Pages: 2348-2351(2013)
- 作者机构：
  
  重庆医药高等专科学校药学系
- 作者简介：
- 基金信息：
- DOI：
  CLC： R943;R284.1;R944.9
- Published：2013，
  
  Published Online：15 November 2013，
- 稿件说明：
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ZHANG YAHONG, LIN FENGYUN, QIU YANCHUAN, et al. Preparation and evaluation of self-microemulsifying drug delivery system for artemether in vitro. [J]. Journal of army medical university, 2013, 35(21): 2348-2351.
DOI：

ZHANG YAHONG, LIN FENGYUN, QIU YANCHUAN, et al. Preparation and evaluation of self-microemulsifying drug delivery system for artemether in vitro. [J]. Journal of army medical university, 2013, 35(21): 2348-2351. DOI：

摘要

目的研究蒿甲醚自微乳化释药系统处方组成和体外特性。方法通过溶解度实验、伪三元相图绘制和正交实验设计筛选优化蒿甲醚自微乳化处方。以自乳化速率、粒径、稳定性和体外溶出度为指标评价自乳化微乳系统体外特性。结果蒿甲醚自微乳化释药系统的最佳处方选择Lauroglycol 90为油相，Cremophor RH 40为乳化剂，Gelucire 44/14为助乳化剂，最佳配比为4∶4∶2，其中蒿甲醚的载药量为80 mg/g。自制的ARM-SMEDDS均在2 min以内完成自微乳化，粒径为(61.50±8.66) nm，常温下3个月基本保持稳定，体外溶出度结果显示120 min即能达到＞99.5%的溶出率，累积溶出百分率为原料药的7倍。结论所制备的ARM-SMEDDS外观和稳定性良好，能显著提高体外溶出度。

Abstract

Objective To prepare and evaluate the self-microemulsifying drug delivery system (SMEDDS) of artemether (ARM)

in vitro

. Methods The preparation process of ARM-SMEDDS was optimized by solubility study

pseudo ternary phase diagrams and orthogonal design. Self-microemulsifying time

average particle size

stability and dissolution

in vitro

were evaluated. Results The optimized formation of ARM-SMEDDS were composed of ARM 80 mg/g

lauroglycol 90 as oil

cremophor RH 40 as surfactant and gelucire 44/14 as co-surfactant with a weight ratio of 4∶4∶2. The ARM-SMEDDS prepared above could self-microemulsify within 2 min

with a particle size of 61.50±8.66 nm. ARM-SMEDDS was found to be stable up to 3 months at room temperature. The percentage of accumulated dissolution was more than 99.5% within 120 min which was 7 fold compared to ARM. Conclusion ARM-SMEDDS has good appearance and stability

and its dissolution

in vitro

is improved significantly.

关键词

蒿甲醚自微乳化释药系统伪三元相图体外评价

Keywords

artemetherself-microemulsifying drug delivery systempseudo-ternary phase diagramsin vitro evaluation

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Related Institution

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Preparation and evaluation of self-microemulsifying drug delivery system for artemether in vitro

DOI：

摘要

Abstract

关键词

Keywords

references