Clinical analysis of chemoradiotherapy combined with bisphosphonates treatment on vertebral metastasis from small cell lung cancer

Feng Yan; Chao Rui; Liu Peng; Wang Dong; Zhao Jianhua

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Clinical analysis of chemoradiotherapy combined with bisphosphonates treatment on vertebral metastasis from small cell lung cancer

更新时间：2025-01-15

- Clinical analysis of chemoradiotherapy combined with bisphosphonates treatment on vertebral metastasis from small cell lung cancer
- Journal of Army Medical University Vol. 36, Issue 6, Pages: 541-544(2014)
- 作者机构：
  
  第三军医大学大坪医院野战外科研究所：肿瘤中心，脊柱外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2;R738.1;R730.53
- Published：2014，
  
  Published Online：30 March 2014，
- 稿件说明：
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FENG YAN, CHAO RUI, LIU PENG, et al. Clinical analysis of chemoradiotherapy combined with bisphosphonates treatment on vertebral metastasis from small cell lung cancer. [J]. Journal of army medical university, 2014, 36(6): 541-544.
DOI：

FENG YAN, CHAO RUI, LIU PENG, et al. Clinical analysis of chemoradiotherapy combined with bisphosphonates treatment on vertebral metastasis from small cell lung cancer. [J]. Journal of army medical university, 2014, 36(6): 541-544. DOI：

摘要

目的通过回顾性研究放化疗和双磷酸盐在治疗小细胞肺癌椎体转移中的作用，探讨小细胞肺癌椎体转移内科治疗方案的选择。方法回顾性分析2010年10月至2012年10月本院所收治的56例小细胞肺癌并发生椎体转移患者的临床资料。根据椎体转移灶治疗方式的不同分为3组：化疗组（

=18）、化疗+双磷酸盐组（

=22）、放化疗+双磷酸盐组（

=16）。对比各组疼痛缓解程度、脊髓功能分级改变、病理性骨折以及不良反应情况。结果随访时间3～24个月，中位随访时间9个月。化疗+双磷酸盐组和放化疗+双磷酸盐组治疗后转移灶骨痛明显缓解（

0.05），其中放化疗+双磷酸盐组疼痛缓解程度较化疗组显著增大(

0.05)。放化疗+双磷酸盐组椎体病理性骨折发生率为6.25%，与化疗组（38.89%）比较显著降低(

0.05)。结论放化疗联合双磷酸盐治疗能够明显减轻小细胞肺癌椎体转移灶的疼痛，并可能预防或延缓病理性骨折的发生。

Abstract

Objective To investigate the medical therapy strategy on vertebral metastasis from small cell lung cancer (SCLC). Methods Fifty-six patients (41 males

15 females) with vertebral metastases from SCLC from October 2010 to October 2012 were retrospectively evaluated. According to therapeutic methods

they were randomly divided into 3 groups

chemotherapy (

=18) group

chemotherapy plus bisphosphonates (

=22) group

and chemoradiotherapy plus bisphosphonates (

=16) group.

Pain relief

spinal cord classification

pathologic fractures

and adverse effect were compared among the groups. Results The follow-up lasted 3-24 months

median 9 months. Patients in both the chemotherapy plus bisphosphonates group and the chemoradiotherapy plus bisphosphonates group gained significant pain relief after treatment (

0.05). The degree of pain relief in the chemoradiotherapy plus bisphosphonates group was significantly higher than that in the chemotherapy group (

0.05). The incidence of pathological vertebral fractures in the chemoradiotherapy plus bisphosphonates group (6.25%) was significantly lower than that in the chemotherapy group (38.89%) (

0.05). Conclusion Chemoradiotherapy combined with bisphosphonates treatment can significantly relieve pain caused by vertebral metastases from SCLC

and may prevent or delay the occurrence of pathological vertebral fractures.

关键词

小细胞肺癌椎体转移放化疗双磷酸盐

Keywords

small cell lung cancervertebral metastasischemoradiotherapybisphosphonates

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