Objective        To investigate the efficacy and compliance of whole course management for depressed patients.       Methods        A total of 100 patients who met with the DSM-Ⅳ diagnostic criteria of depressive episodes and freshly diagnosed depression in our clinic from January 2011 to March 2013 were enrolled in this prospective parallel controlled study. The cohort of patients was random divided into 2 groups

wi

th no significant difference in age

sex

educational levels and scores of psychological scales. One group received a full course of management services

and another group received conventional treatment. All the patients were followed up for 6 months. Patient compliance was assessed by Morisky’s compliance scale and the efficiency was evaluated by 17-item Hamilton depression scale (HAMD) before and in 1

3 and 6 month after treatment.       Results        There was no significant difference between 2 groups in compliance scale score in the first month after treatment (

P

>0.05)

but the score was significantly higher in the whole course management group than the control group in 3 and 6 months after treatment (

P

<

0.05

P

<

0.01). The HAMD scale score in the control group was significant lower in 1 and 3 months after than before treatment (

P

<

0.05)

but no such difference was seen in 6 month after treatment (

P

>0.05). However

the score of the whole course management group was significantly reduced in 1

3 and 6 month after treatment than before treatment (

P

<

0.05)

and the values were in a time-dependent manner. No significant difference was seen in the score in 1 month after treatment (

P

>0.05)

the whole course management group had significantly lower scores than the control group in 3 and 6 months after treatment (

P

<

0.05).       Conclusion       Whole course management improves the compliance and efficacy in depressed patients.