Medical biochemistry is a very important basic curricular in medicine teaching. But its theory is abstract， so it is difficult for teachers to teach. On the other hand， the students feel it hard to learn too， because they don't know how these theories are applied. We have applied case-based teaching in medi-cal biochemistry teaching. These methods effectively improve students' enthusiasm to study and to train their scientific thinking in preliminary. Following this way we have explored a new way to elevate teaching qualities and search new teaching model and to further reform present medical biochemistry teaching model.