Through the excellent experiment of cardiovascular system in pathology， the prac-tice of the teaching reform was carried out such as combining flow model with real specimens， digital sections with light microscope slides， inserting the use of special staining experiments in combination with digital medical image analysis and the simulation of cardiovascular clinical pathological case dis-cussions. Linking theory with experiment teaching and experiment teaching with clinical practice was focused on， which not only stimulated students' interest in learning and their exploring thinking and hands-on ability， but also promoted them to obtain good learning effect， thus improving the teaching quality.