Objective　To explore the teaching effect of Organ-system-based curriculum in-tegrated model on clinical graduation field work. Method　150 clinical medical undergraduates of Grade 2009 from Shenyang Medical College selected

were randomly divided into the experimental group (75 persons) and the control group (75 persons). The experimental group adopted the means of the Organ-system-based curriculum integrated model

namely practicing according to human organ-system and the control group accepted the traditional pattern of discipline centered practice during the clinical graduation internship. The two groups of students carried out questionnaire survey and comprehend examinations when the practice ended

and then statistics analysis (the chi square test

t test) was done by the SPSS 19.0 software between the two groups in order to explore the teaching effect. Result　The students' satisfaction degree from six aspects of the questionnaire survey showed in the experimental group was significantly higher than that in the control group (the degree of recognition of practicing pattern: χ2=11.437

P=0.003; the architectonic integrality: χ2=9.881

P=0.007; the im-provement of the autonomic learning ability χ2=9.643

P=0.008; the teaching method and means: χ2=11.006

P=0.004; motivating learning interest: χ2=13.550

P=0.001; increasing the ability of clinical thinking: χ2=13.309

P=0.001)

and the average test scores of students from three parts of examination results showed by comprehend examinations (speculative knowledge examination: t=2.768

P=0.006; technical skill examination: t=2.212

P=0.029; clinical capability examination: t=5.015

P=0.000) in the experimental group was obviously higher than that in the control group and the difference was sig-nificant. Conclusion　Organ-system-based curriculum integrated model on clinical graduation in-ternship is generally approved by the students

which has significantly improved the students' clinical thinking ability

and the quality of graduation internship teaching.