Objective　Based on small private online course (SPOC)

the flipped classroom that integrates various teaching models can combine the advantages of different methods

which needs to be further discussed and practiced in the university classroom

especially in medical education. Methods　This study took two classes of grade three majoring in clinical medicine as targets to apply the team-based learning and flipped classroom based on SPOC in the course of diseases screening for preventive medicine. We prepared teaching video

proposed questions

assigned student discussions

and carried out online communications before the classes. During the classes

we organized small tests

and applied team-based reports

discussions and teachers’ evaluation. The responses of students were collected by questionnaires after the classes. We evaluated the teaching effectiveness basing on questionnaire results. Chi-square test and Fisher exact test were performed in the analysis of impact factors on students’ preferred learning mode. Results　We received 81 effective questionnaires. A total of 75.31% students (61/81) thought the blended learning mode was interesting. Majority (93.83%

76/81) of them believed this type of learning was helpful to understand the concept. Comparing with traditional classroom

students who felt interesting were more likely to choose the blended learning mode

and the difference was of statistical significance ( ?字2=6.01

P=0.028). Students who felt helpful and spent less time in preparation preferred the blended learning mode. Conclusion　Blended learning mode avoids many disadvantages of traditional classroom and can improve learners' interest

motivation and sense of participation

providing an effective way to improve the quality of medical education.