A descriptive study to investigate the situation of cross-cultural adaptation and health status among medical international students was carried out using cluster sampling method and self-de-signed questionnaire in Dalian Medical University. 148 international students come from 24 countries. There are 5 religions belief among these students. Islam， Catholic， Hindu， Buddhism and Sikhism. The main obstacles of cross-cultural adaptation are language， accommodation and diet. Economic status and stress of interpersonal relationship are also the main causes affecting the physical and mental health of medical international students.