Objective　To evaluate the teaching effects of case introduced method based on pic-ture archiving and communication system（PACS） system in medical imaging course. Methods　Totally 148 students （2009 grade） majored in five-year clinical medicine from Xiangya Medical College were divided into 10 groups； the 10 groups were taken randomly as control group（n=75） and experimental group（n=73）. Control group used traditional teaching methods（film teaching） while experimental group used case introduced method based on PACS system. Effects of teaching between were evaluated by questionnaire and test. χ2 test was used to compare students' theoretical test scores， with α level = 0.05. Results　Based on results of questionnaires， more students in experimental group than in control group hold that case introduced method based on PACS system can achieve the purpose of teaching， improve interests in learning， and strengthen the mastery of knowledge. Test scores showed that the percentage of students scored 90-100 and 80-89 （respectively 14%， 75%） in experimental group was significantly higher than that in control group （respectively 5%， 66%） （χ2 =17.932， P=0.000）. Conclusions　Application of case introduced method based on PACS system in medical imaging course not only improve students' motivation to learn and their clinical ability， but also allow teachers to find and correct short-comings of students timely， therefore， it is worth promoting.