It is to difficult to diagnose and treat hepatobiliary surgical diseases since its diverse clinical manifestations， which increases the difficulty of clinical internship. Taking clinical cases as tea-ching material， case-based learning was combined with teaching theme and was conducted by means of discussion and question and answer between teachers and students. Students can know about concepts or theories related to teaching theme. Case-based learning in internship can consolidate basic knowledge of hepatobiliary surgery， cultivate clinical scientific thinking and is helpful in analyzing and resolving prob-lems of hepatobiliary surgical diseases.