Objective　To evaluate the effect of applying emergency care simulator（ECS） on cardiopulmonary resuscitation skill training. Methods　Clinical doctors and nurses（n=1 472） received the skill training of unarmed cardiopulmonary resuscitation（CPR）， electric defibrillation and tracheal intubation by using simple CPR simulator （n=667） or ECS （n=805） respectively. After training， the examination was carried out and questionnaires were handed out. The completion time of operations， the scores and pass rates of examinations， the evaluations of training methods were compared between the two groups. The statistical data were analyzed by t（t'）-test or Chi-square test with SPSS 19.0 and P <0.05 was considered as the criterion of significance. Results　Compared with those of group using simple CPR simulator， the group using ECS showed obviously shortened completion time（（309±125） s vs. （242±61） s， t'=12.65， P=0.00；（87±36） s vs. （55±31） s， t'=20.28， P=0.00；（239±87） s vs. （145±53）， t'=24.4， P=0.00）， significantly increased scores （（83.5±14.8） vs. （90.2±17.6）， t'=7.93， P=0.00； （84.7±19.3） vs. （92.1±21.5）， t'=6.95， P=0.00； （81.6±15.3） vs. （89.6±13.5）， t'=10.53， P=0.00） and pass rates of examinations （84.1%（561/667） vs. 92.5%（745/805）， χ2=25.96，P<0.01； 82.2%（548/667） vs. 91.2%（734/805）， χ2=26.41， P<0.01； 80.8%（539/667） vs. 91.4%（736/805）， χ2=35.48，P<0.01） as well as higher evaluation of training methods. Conclusions　Application of ECS can obviously improve the training effect of CPR and it can be widely popularized in the edu-cation and training of emergency medicine skills.