Double main teaching model can be applied in the teaching of pharmacology. To be spe-cific， for complex and difficult theory， we applied 'transmission-acceptancee' teaching method while for simple and easy theory， we used 'discovery' teaching method. Compared with the traditional teaching mod-el， double main teaching model improved teaching results and enhanced students' enthusiasm for learn-ing， their autonomous learning ability and cooperative ability. On the other hand， there still existed some prob-lems. We should keep on making great efforts to achieve better teaching results.