With the development of the health service in china， the old talent-training program for clinical medicine major was failed in meeting higher demands for talents of clinical medicine. To create the new talent-training program， therefore， has become the main content of teaching reform for medical col-leges and universities. Taking University of South China as an example， the paper analyzed the changing trend of talent-training program for five-year clinical medicine majors from talent-training goal， curriculum system， practical teaching and content of courses， which proposed some thoughts on the optimization of training program for clinical medicine majors.