Objective　To clarify the role of the virtual reality （VR） in the training of trans-femoral cerebral angiography for novices without any experience of intravascular manipulation. Methods　Twenty-four novices without experiences of intravascular manipulation were divided into 2 groups （VR group or control group） with random pair method concerning the age， gender and subjects. The par-ticipants in control group were trained in routine manners while those in VR group practiced on a simulator and subsequently participated in real angiography once as assistants. Real angiography tests were performed for all participants after the training session and additional angiography tests were per-formed for VR group just after the stimulation session on the simulator. Real angiography tests were supervised and scored according to a modified rating scale by neuroradiological experts who were blinded to the novices' training procedures. Difference between the real test performance of the two groups were compared by pared-samples t test， while the correlation between the performance of the real tests and simulator tests of VR group was proved by Pearson correlation analysis. P<0.05 was con-sidered statistically significant. Results　The mean scores of VR group were （27.6±3.6） and （26.4±3.8） in the tests on simulator and real angiography tests respectively， while score of control group was （21.2±3.4） in the real angiography tests. A positive correlation was revealed in VR group between performance on the simulator and that on real patients （r=0.825， P=0.001）. Real performance of the VR group was significantly better than that of control group （P=0.010）. Conclusions　Virtual reality could ensure transfer of acquired endovascular skills from simulators to patients so as to become a valid tool for novices to improve the interventional techniques in tranfemoral cerebral angiography.