Objective　To compare the effect of four-in-one teaching method and traditional teaching method in clinical clerkship teaching in the department of obstetrics and gynecology. Methods　 Totally 70 clinical probationer were enrolled（35 from 2007 grade were taken as control group and 35 from 2008 grade were taken as experiment group）. Four-in-one teaching method and traditional teaching method were respectively in experiment group and control group. Examination score and clinical skill re-sults were analyzed by t test and satisfaction degree was analyzed by ?字2 test. P<0.05 signifies statistical sig-nificances. Results　Examination score of experiment group and control group were 86.9±7.7 and 76.5±8.7 respectively with statistically significant differences（P=0.000）. Clinical skill score of experi-ment group and control group were 87.6±6.9 and 75.9±7.5 respectively with statistically significant dif-ferences （P=0.000）. Each questionnaire index was significantly higher in experiment group than in con-trol group with statistically significant differences（P=0.000）. Conclusions　Four-in-one teaching method can make students understand theoretical knowledge and master obstetrics and gynecology basic clinical skills， enhance interests in learning， build up self-confidence and establish preliminary clinical thinking ability and innovation ability which will lay a solid foundation for future clinical and research practice.