According to the requirements of the ‘three guidance’ talent-cultivation model pro-posed by our university， humanistic spirit was permeated from multi angels during the process of phys-iology. Students'occupation quality was cultivated； physiology knowledge and clinical practice was combined for students； early contacting with clinical knowledge was conducted and teacher-student role reversal method was applied to train students' communication skills. Teaching practice showed that the reformed teaching model not only can ensure the quality of teaching but also can improve the comprehensive quality of students.